US 11,872,255 B2
Methods and compositions of preventing and treating dental caries
Pooja Balani, Melrose, MA (US); Felicitas Bidlack, Somerville, MA (US); Xuesong He, Cypress, CA (US); Megan Pugach-Gordon, Medford, MA (US); Wenyuan Shi, Winchester, MA (US); Jacqueline Starr, Lexington, MA (US); and Daniel Ferrer, Boston, MA (US)
Assigned to Forsyth Dental Infirmary for Children, Cambridge, MA (US)
Filed by Forsyth Dental Infirmary for Children, Cambridge, MA (US)
Filed on Jan. 13, 2022, as Appl. No. 17/575,160.
Application 17/575,160 is a continuation of application No. 17/119,933, filed on Dec. 11, 2020, granted, now 11,246,895.
Application 17/119,933 is a continuation of application No. PCT/US2020/063343, filed on Dec. 4, 2020.
Claims priority of provisional application 62/944,717, filed on Dec. 6, 2019.
Prior Publication US 2022/0241355 A1, Aug. 4, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/00 (2006.01); A61K 35/747 (2015.01); A61K 6/00 (2020.01)
CPC A61K 35/747 (2013.01) [A61K 6/00 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method of preventing dental caries in a subject comprising increasing the pH of the oral cavity of a subject in need thereof,
wherein increasing the pH of the oral cavity of the subject comprises administering to the oral cavity of the subject a therapeutically effective amount of a bacterial composition comprising a bacterium of species Rothia denticariosa, a bacterium of species Rothia aeria, or a combination thereof.