US 11,872,248 B2
Nucleic acids encoding chimeric receptor comprising NKP30 receptor and CD28 and CD3 zeta domains and human T cell containing
Tong Zhang, Lebanon, NH (US); and Charles L. Sentman, Grantham, NH (US)
Assigned to THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed by THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed on May 26, 2020, as Appl. No. 16/882,800.
Application 16/882,800 is a division of application No. 15/830,605, filed on Dec. 4, 2017, granted, now 10,682,378.
Application 15/830,605 is a division of application No. 14/342,060, granted, now 9,833,476, issued on Dec. 5, 2017, previously published as PCT/US2012/053511, filed on Aug. 31, 2012.
Claims priority of provisional application 61/529,410, filed on Aug. 31, 2011.
Prior Publication US 2020/0360434 A1, Nov. 19, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/62 (2006.01); A61K 35/17 (2015.01); C07K 14/705 (2006.01); C12N 15/00 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); A61K 38/00 (2006.01)
CPC A61K 35/17 (2013.01) [C07K 14/70503 (2013.01); C07K 14/70521 (2013.01); C07K 14/70575 (2013.01); C07K 14/70578 (2013.01); C07K 14/70596 (2013.01); C07K 16/2803 (2013.01); C12N 5/0636 (2013.01); C12N 15/00 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01); C12N 2800/22 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A nucleic acid construct that encodes for and which when introduced into a cell provides for the expression of a chimeric receptor comprising: a first nucleic acid sequence comprising a promoter operably linked to a second nucleic acid sequence, wherein said second nucleic acid sequence encodes a chimeric NKp30 receptor comprising: an NKp30 extracellular domain, CD28 transmembrane and cytoplasmic domains and a CD3ζ signaling domain.