US 11,872,245 B2
Antiseptic polymer and synthesis thereof
Ali Fathi, Paddington (AU); and Fariba Dehghani, Killarney Heights (AU)
Assigned to TRIMPH IP PTY LIMITED, Sydney (AU)
Filed by TRIMPH IP PTY LIMITED, Sydney (AU)
Filed on Dec. 21, 2021, as Appl. No. 17/557,108.
Application 17/557,108 is a continuation of application No. 15/746,810, granted, now 11,219,639, previously published as PCT/AU2016/050653, filed on Jul. 22, 2016.
Claims priority of application No. 2015902943 (AU), filed on Jul. 24, 2015.
Prior Publication US 2022/0125828 A1, Apr. 28, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/74 (2006.01); A61K 47/58 (2017.01); A61K 47/59 (2017.01); A61K 47/06 (2006.01); A61K 47/69 (2017.01); A61K 47/60 (2017.01); A61K 31/78 (2006.01); A61L 27/16 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); A61L 15/24 (2006.01); A61L 24/04 (2006.01); A61L 26/00 (2006.01); A61K 47/61 (2017.01)
CPC A61K 31/74 (2013.01) [A61K 31/78 (2013.01); A61K 47/58 (2017.08); A61K 47/593 (2017.08); A61K 47/60 (2017.08); A61K 47/61 (2017.08); A61K 47/6903 (2017.08); A61L 27/16 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01)] 15 Claims
 
1. A method of surgical sealing comprising administering to a subject in need thereof an effective amount of a polymer consisting of:
at least one antiseptic monomeric unit comprising a methacrylic ester derivative of salicylic acid selected from 2-hydroxy-5-N-methacrylamidobenzoic acid (5-HMA), 2-hydroxy-4-N-methacrylamidobenzoic acid (4-HMA), and a combination thereof;
a water-soluble monomeric unit in the form of an oligo(ethylene glycol) methyl ether methacrylate (OEGMA) moiety;
a mechanical strength-conferring monomeric unit in the form of polylactide-co-2-hydroxy-ethylmethyl acrylate (PLA/HEMA);
a protein/polysaccharide-reactive monomeric unit in the form of an N-acryloxysuccinimide (NAS) moiety; and
a thermosetting monomeric unit in the form of an N-isopropyl acrylamide (NIPAAm) moiety.