US 11,872,111 B2
Patches for localized use
Catherine Shachaf, Los Gatos, CA (US)
Assigned to ORLUCENT INC.
Filed by ORLUCENT INC., Los Gatos, CA (US)
Filed on Mar. 23, 2021, as Appl. No. 17/209,369.
Prior Publication US 2022/0304864 A1, Sep. 29, 2022
Int. Cl. A61F 13/02 (2006.01); A61L 15/22 (2006.01); A61F 13/00 (2006.01)
CPC A61F 13/0259 (2013.01) [A61L 15/22 (2013.01); A61F 2013/00097 (2013.01); A61F 2013/00285 (2013.01); A61L 2300/442 (2013.01); A61L 2300/45 (2013.01); A61L 2400/12 (2013.01)] 16 Claims
 
1. A device comprising a patch comprising:
(i) a substrate, wherein the substrate is selected from the group consisting of ethane-acetic acid ethenyl ester, polyvinyl alcohol, ethyl cellulose, Polylactic acid, poly-ε-caprolactone (PCL) film and triglycidylamine;
(ii) an adhesive on the substrate, wherein the adhesive is selected from the group consisting of an epoxyamine, methyl acrylate, ethyl acrylate, ethyl methacrylate, methyl methacrylate, n-butyl acrylate, n-butyl methacrylate, n-pentyl acrylate, n-hexyl acrylate, n-heptyl acrylate, and n-octyl acrylate, and a branched (meth)acrylic isomer selected from i-butyl acrylate, i-butyl methacrylate, n-butyl methacrylate, 2-ethylhexyl acrylate, stearyl methacrylate or isooctyl acrylate;
(iii) a pocket under the substrate prefilled with a first material and a second material, wherein the first material is a combination of penetration enhancer and dye; wherein the penetration enhancer is selected from the group consisting of ethanol, isopropyl alcohol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyl dodecanol, oleyl alcohol;
(iv) an opening in the substrate, and
(v) a flap, wherein the flap covers the opening and is different than the substrate, and is configured for the introduction of materials in the patch; and
wherein the patch is configured to:
(a) attach to a skin via the adhesive to form the pocket between the patch and a skin, wherein the adhesive circumscribes the pocket,
(b) allow introduction of a second material into the pocket through the opening, and
(c) hold the first material and the second material within the pocket;
wherein the first material is configured to activate under a specific condition by reacting the first material with the second material; wherein the device is configured to image a portion of the skin on which the patch is placed.