US 11,872,022 B2
System and method for an optical blood flow measurement
Maria Angela Franceschini, Charlestown, MA (US); Stefan Carp, Boston, MA (US); Davide Tamborini, Charlestown, MA (US); David Boas, Charlestown, MA (US); Bruce Rosen, Charlestown, MA (US); Megan Blackwell, Charlestown, MA (US); and Oleg Shatrovoy, Charlestown, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US); and Massachusetts Institute of Technology, Cambridge, MA (US)
Appl. No. 16/970,670
Filed by THE GENERAL HOSPITAL CORPORATION, Boston, MA (US)
PCT Filed Feb. 18, 2019, PCT No. PCT/US2019/018423
§ 371(c)(1), (2) Date Aug. 18, 2020,
PCT Pub. No. WO2019/161336, PCT Pub. Date Aug. 22, 2019.
Claims priority of provisional application 62/631,927, filed on Feb. 18, 2018.
Prior Publication US 2020/0375476 A1, Dec. 3, 2020
Int. Cl. A61B 5/026 (2006.01); G01J 1/44 (2006.01); H01L 31/107 (2006.01); H01L 31/109 (2006.01)
CPC A61B 5/0261 (2013.01) [G01J 1/44 (2013.01); A61B 2562/0233 (2013.01); G01J 2001/448 (2013.01); G01J 2001/4453 (2013.01); G01J 2001/4466 (2013.01); H01L 31/107 (2013.01); H01L 31/109 (2013.01)] 24 Claims
OG exemplary drawing
 
1. An apparatus, comprising:
a probe to interface with a surface of a tissue;
a first light source optically coupled to the probe,
the first light source providing light of up to 900 nm into the tissue;
a second light source optically coupled to the probe,
the second light source providing light of at least 1000 nm into the tissue;
a first detector optically coupled to the probe,
the first detector to detect light scattered in the tissue from the first light source, and
the first detector having a light sensitivity in a range of up to 900 nm;
a second detector optically coupled to the probe,
the second detector to detect light scattered in the tissue from the second light source, and
the second detector having a light sensitivity in a range of at least 1000 nm; and
a processor coupled to the first detector and the second detector, the processor to:
receive a first signal from the first detector corresponding to the detected light from the first light source,
receive a second signal from the second detector corresponding to the detected light from the second light source, and
determine a blood flow measurement from the region of interest based on the first signal and the second signal.