US 11,871,995 B2
Patient-specific modeling of hemodynamic parameters in coronary arteries
Andrzej Kosior, Wroclaw (PL); Kryspin Mirota, Wroclaw (PL); and Wojciech Tarnawski, Wroclaw (PL)
Assigned to Hemolens Diagnostics Sp. z o.o., Wroclaw (PL)
Filed by HEMOLENS DIAGNOSTICS SP. Z.O.O., Wroclaw (PL)
Filed on Dec. 12, 2018, as Appl. No. 16/217,328.
Claims priority of provisional application 62/599,930, filed on Dec. 18, 2017.
Prior Publication US 2019/0183579 A1, Jun. 20, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 34/10 (2016.01); A61B 6/03 (2006.01); A61B 6/00 (2006.01); A61B 5/021 (2006.01); G16H 10/60 (2018.01); G16H 50/50 (2018.01); G16H 30/40 (2018.01); A61B 5/026 (2006.01); A61B 5/02 (2006.01); A61B 5/00 (2006.01)
CPC A61B 34/10 (2016.02) [A61B 5/0044 (2013.01); A61B 5/021 (2013.01); A61B 5/02007 (2013.01); A61B 5/02028 (2013.01); A61B 5/0263 (2013.01); A61B 6/032 (2013.01); A61B 6/504 (2013.01); A61B 6/507 (2013.01); A61B 6/5217 (2013.01); A61B 6/5247 (2013.01); G16H 10/60 (2018.01); G16H 30/40 (2018.01); G16H 50/50 (2018.01); A61B 2034/105 (2016.02); A61B 2034/108 (2016.02); A61B 2505/05 (2013.01); A61B 2576/023 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of generating a coronary artery model comprising:
receiving patient-specific anatomical structure data and patient-specific physiological data, wherein the anatomical structure data comprises structural information about a patient's coronary arteries, and wherein the patient-specific physiological data comprises a continuously recorded blood pressure waveform from a non-invasive measurement;
generating, based at least in part on the anatomical structure data, an anatomical model of at least a portion of the patient's coronary arteries;
generating an inflow or an outflow waveform boundary condition for a computational fluid dynamics (CFD) simulation of blood flow in the anatomical model by:
(i) assigning the continuously recorded blood pressure waveform as the boundary condition, and
(ii) using the continuously recorded blood pressure waveform to model the boundary condition;
simulating blood flow in the anatomical model using CFD and the inflow or the outflow waveform boundary condition for the CFD simulation of blood flow; and
determining, based at least in part on the simulation, one or more hemodynamic parameters associated with the patient's coronary arteries,
thereby generating a coronary artery model.