	US 12,195,808 B2
	Dynamic changes in circulating free RNA of neural tumors
Shahrooz Rabizadeh, Agoura Hills, CA (US)
Assigned to NantOmics LLC, Culver City, CA (US)
Filed by Nantomics LLC, Culver City, CA (US)
Filed on Aug. 9, 2023, as Appl. No. 18/447,117.
Application 18/447,117 is a division of application No. 16/639,543, granted, now 11,821,043, previously published as PCT/IB2018/056225, filed on Aug. 17, 2018.
Claims priority of provisional application 62/547,047, filed on Aug. 17, 2017.
Prior Publication US 2023/0383366 A1, Nov. 30, 2023
Int. Cl. C12Q 1/6886 (2018.01)

CPC C12Q 1/6886 (2013.01) [C12Q 2600/106 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01)]

20 Claims

1. A method of determining a prognosis of a neural cancer of a patient, comprising:

obtaining a first sample of a bodily fluid of the patient;

detecting a plurality of changes of one or more cfRNA in the first sample, wherein the plurality of changes are related to a prognosis of the neural cancer, wherein the cfRNA is specific to at least one of the neural cancer, a DNA repair status, and an immune status, and wherein the neural cancer is a glioma, a glioblastoma, or a neuroblastoma; and

determining the prognosis of the neural cancer based on an interrelationship among the plurality of changes and/or a predetermined threshold of at least one of the plurality of changes.