	US 11,867,702 B2
	Detection of pathological protein aggregation
Marzena Kurzawa-Akanbi, Newcastle upon Tyne (GB); and Christopher Mile Morris, Newcastle upon Tyne (GB)
Assigned to UNIVERSITY OF NEWCASTLE UPON TYNE, Newcastle upon Tyne (GB)
Appl. No. 16/978,244
Filed by UNIVERSITY OF NEWCASTLE UPON TYNE, Newcastle upon Tyne (GB)
PCT Filed Mar. 5, 2019, PCT No. PCT/GB2019/050599 § 371(c)(1), (2) Date Sep. 4, 2020, PCT Pub. No. WO2019/171035, PCT Pub. Date Sep. 12, 2019.
Claims priority of application No. 1803553.5 (GB), filed on Mar. 6, 2018.
Prior Publication US 2020/0408782 A1, Dec. 31, 2020
Int. Cl. G01N 33/68 (2006.01)

CPC G01N 33/6896 (2013.01) [G01N 2800/2835 (2013.01)]

9 Claims

1. An in vitro method of determining the presence of pathological alpha-synuclein protein in a subject, the method comprising:

(a) providing an enriched extracellular vesicle sample from the subject; and

(b) determining the presence of the pathological alpha-synuclein protein in the extracellular vesicle sample with a protein amplification based assay.