US 11,867,694 B2
Latex particles for measurement reagents, sensitized latex particles, and measurement reagent for turbidimetric immunoassay
Satoru Sugimoto, Mishima-gun (JP); Takeshi Wakiya, Mishima-gun (JP); Shinichiro Kitahara, Tokyo (JP); Maasa Yaji, Tokyo (JP); and Yuya Inaba, Tokyo (JP)
Assigned to SEKISUI MEDICAL CO., LTD., Tokyo (JP)
Appl. No. 16/616,371
Filed by SEKISUI CHEMICAL CO., LTD., Osaka (JP); and SEKISUI MEDICAL CO., LTD., Tokyo (JP)
PCT Filed May 24, 2018, PCT No. PCT/JP2018/020076
§ 371(c)(1), (2) Date Nov. 22, 2019,
PCT Pub. No. WO2018/216784, PCT Pub. Date Nov. 29, 2018.
Claims priority of application No. 2017-103093 (JP), filed on May 24, 2017.
Prior Publication US 2020/0080996 A1, Mar. 12, 2020
Int. Cl. G01N 33/546 (2006.01); C08F 12/32 (2006.01); C08F 12/08 (2006.01); C08F 22/20 (2006.01); C08F 28/06 (2006.01)
CPC G01N 33/546 (2013.01) [C08F 12/08 (2013.01); C08F 12/32 (2013.01); C08F 22/20 (2013.01); C08F 28/06 (2013.01)] 8 Claims
OG exemplary drawing
 
1. Latex particles for measurement reagents having a coefficient of variation in particle diameters of 10% or less and an average particle diameter of 250 nm to 1000 nm,
wherein the latex particles each contain 20% by weight or more of a compound having a refractive index of 1.60 or more,
the depth of a supernatant is 5 mm or less when a liquid dispersion having a solid matter concentration of 1% by weight, which is prepared by dispersing the latex particles in ultrapure water, is placed in a 10-ml measuring cylinder having a body inner diameter of 10.8 mm and is then left for 10 days,
wherein the compound having a refractive index of 1.60 or more includes a compound having at least one skeleton selected from the group consisting of a fluorene skeleton, a dinaphthothiophene skeleton, a naphthalene skeleton, an anthracene skeleton and a phenanthrene skeleton,
wherein the latex particles have a porous hollow structure having two or more hollow structures.