US 11,867,654 B2
Device and method for detecting creatinine and albumin to creatinine ratio
Vinay Kumar, Bangalore (IN); Navakanta Bhat, Bangalore (IN); and Nikhila Kashyap Dhanvantari Madhuresh, Bangalore (IN)
Assigned to Indian Institute of Science, Bangalore (IN)
Appl. No. 15/573,686
Filed by INDIAN INSTITUTE OF SCIENCE, Bangalore (IN)
PCT Filed Jan. 22, 2016, PCT No. PCT/IB2016/050311
§ 371(c)(1), (2) Date Nov. 13, 2017,
PCT Pub. No. WO2016/181229, PCT Pub. Date Nov. 17, 2016.
Claims priority of application No. 2412/CHE/2015 (IN), filed on May 12, 2015.
Prior Publication US 2018/0149612 A1, May 31, 2018
Int. Cl. G01N 27/327 (2006.01); G01N 33/543 (2006.01); G01N 33/493 (2006.01); A61B 5/145 (2006.01); A61B 5/1468 (2006.01); G01N 27/48 (2006.01); G01N 33/68 (2006.01); G01N 33/70 (2006.01)
CPC G01N 27/3277 (2013.01) [A61B 5/1468 (2013.01); A61B 5/14507 (2013.01); A61B 5/14546 (2013.01); G01N 27/327 (2013.01); G01N 27/48 (2013.01); G01N 33/493 (2013.01); G01N 33/5438 (2013.01); G01N 33/68 (2013.01); G01N 33/70 (2013.01); G01N 2333/76 (2013.01); G01N 2333/765 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A device, comprising:
(i) a first electrode member, comprising either two or three electrodes, wherein said first electrode member is in chemical contact with an electrochemically active urine albumin receptor, said urine albumin receptor selected from the group consisting of hemin and hemin in combination with methylene blue:
(ii) a second electrode member, comprising either two or three electrodes, wherein said second electrode member is in chemical contact with an electrochemically active urine creatinine receptor, said urine creatinine receptor comprising an electrochemically active metal or a combination of an electrochemically active metal and methylene blue (MB), wherein the electrochemically active metal is selected from the group consisting of:
(a) Fe+2 ions,
(b) Fe+3 ions,
(c) Pd+2 ions, and
(d) Pt+2 ions
wherein said first and second electrode members are arranged upon a substrate.