US 11,867,596 B2
Chemical sensors with non-covalent, electrostatic surface modification of graphene
Xue Zhen, Plymouth Meeting, PA (US); Philippe Pierre Joseph Buhlmann, Minneapolis, MN (US); Steven J. Koester, Edina, MN (US); and Justin Theodore Nelson, Vadnais Heights, MN (US)
Assigned to REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
Filed by REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
Filed on Mar. 29, 2022, as Appl. No. 17/707,214.
Application 17/707,214 is a continuation of application No. 16/393,177, filed on Apr. 24, 2019, granted, now 11,293,914.
Claims priority of provisional application 62/662,305, filed on Apr. 25, 2018.
Prior Publication US 2022/0291198 A1, Sep. 15, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/497 (2006.01); G01N 27/12 (2006.01); G01N 27/22 (2006.01)
CPC G01N 33/497 (2013.01) [G01N 27/125 (2013.01); G01N 27/227 (2013.01); G01N 2610/00 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A medical device comprising:
a graphene layer;
a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a π-electron system of graphene; and
wherein the self-assembled monolayer comprises one or more substituted porphyrins or substituted metalloporphyrins of the formula:

OG Complex Work Unit Chemistry
wherein each X is independently a heteroatom comprising N, O, P, S, Se, or Si, or absent, such that R is covalently attached to the phenyl group;
wherein each R functional group independently comprises: —H; any linear or branched C1-C50 alkyl, C1-C50 alkenyl, C1-C50 alkynyl, C1-C50 heteroalkyl, C1-C50 heteroalkenyl, C1-C50 heteroalkynyl, or any combination thereof; —RZR, —ZRZR, or—RZRZR, wherein R comprises any identical or different, linear or branched, C1-C50 alkyl, C1-C50 alkenyl, C1-C50 alkynyl, or any combination thereof, and Z can be one or more heteroatom selected from N, O, P, S, Se, or Si; an aryl, heteroaryl, substituted aryl, or substituted heteroaryl; a biphenyl or substituted biphenyl; an aryloxy, arylthio, arylamine, or any substitutions thereof; or any combination thereof; and
wherein M is a metal comprising aluminum, calcium, magnesium, manganese, iron, cobalt, nickel, zinc, ruthenium, palladium, silver, platinum, indium, tin, copper, rhodium, chromium, gallium, osmium, iridium, or derivatives thereof and wherein an oxidation state of the metal comprises I, II, III, IV, V, VI, VII, or VIII.