CPC C12Q 1/485 (2013.01) [A61P 25/28 (2018.01); A61K 31/496 (2013.01); C07D 241/04 (2013.01); G01N 2500/10 (2013.01)] | 4 Claims |
1. A method of treating or inhibiting a disease in a subject, comprising administering to said subject a compound having a structure according to Formula (I):
wherein R1 is a substituted or unsubstituted, 5-6 membered carbocyclic or heterocyclic aromatic ring, wherein said ring is directly attached to the carbonyl substituent of the piperazine ring in Formula (I);
R2 is a substituted or unsubstituted, carbocyclic or heterocyclic, 5-6 membered aromatic ring; and
X1 is S and X2 is O, wherein said disease is associated with elevated p38 mitogen-activated protein kinase (MAPK) enzymatic activity in a cell in said subject, thereby treating or inhibiting said disease in said subject.
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