	US 11,866,708 B2
	Tailored modulation of gene regulation programs via functional enhancer RNA
Tae Hoon Kim, Plano, TX (US)
Assigned to Board of Regents, The University of Texas System, Austin, TX (US)
Filed by Board of Regents, The University of Texas System, Austin, TX (US)
Filed on Oct. 21, 2020, as Appl. No. 17/076,696.
Claims priority of provisional application 62/924,569, filed on Oct. 22, 2019.
Prior Publication US 2021/0115450 A1, Apr. 22, 2021
Int. Cl. C12N 15/113 (2010.01)

CPC C12N 15/1136 (2013.01) [C12N 2310/11 (2013.01)]

8 Claims

1. A method of inhibiting a TNFSF10 gene expression in a human cell comprising contacting the human cell with a single-stranded antisense compound comprising a sequence selected from SEQ ID NOs: 170, 171, 172, 213, 214, 215, 187, 230, 198, 199, 200, 241, 242, or 243, thereby inhibiting expression of the TNFSF10 gene in the human cell.