US 11,866,515 B2
Hemiasterlin derivatives for conjugation and therapy
Toni Kline, San Francisco, CA (US); Qun Yin, Palo Alto, CA (US); and Krishna Bajjuri, Fremont, CA (US)
Assigned to SUTRO BIOPHARMA, INC., South San Francisco, CA (US)
Filed by SUTRO BIOPHARMA, INC., South San Francisco, CA (US)
Filed on Nov. 2, 2020, as Appl. No. 17/087,594.
Application 17/087,594 is a continuation of application No. 15/011,388, filed on Jan. 29, 2016, granted, now 10,844,090.
Claims priority of provisional application 62/110,390, filed on Jan. 30, 2015.
Prior Publication US 2021/0198314 A1, Jul. 1, 2021
Int. Cl. C07K 5/083 (2006.01); C07K 5/02 (2006.01); A61K 47/68 (2017.01); C07K 9/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/40 (2006.01); C07K 5/065 (2006.01); A61K 38/00 (2006.01)
CPC C07K 5/0808 (2013.01) [A61K 47/6817 (2017.08); C07K 5/0205 (2013.01); C07K 9/003 (2013.01); C07K 16/28 (2013.01); C07K 16/30 (2013.01); C07K 16/40 (2013.01); A61K 38/00 (2013.01); A61K 47/6855 (2017.08); C07K 5/06078 (2013.01); C07K 2317/76 (2013.01)] 12 Claims
 
1. A compound according to Formula 1000:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof, wherein:
Ar is a divalent six-membered, substituted or unsubstituted, monocyclic aryl; divalent five- or six-membered, substituted or unsubstituted, monocyclic heteroaryl; divalent nine- or ten-membered, substituted or unsubstituted, monocyclic aryl; or a divalent eight-, nine- or ten-membered, substituted or unsubstituted, fused bicyclic aryl or heteroaryl;
L is absent or —CH2—;
X is

OG Complex Work Unit Chemistry
R is hydrogen; and
W1, W2, W3, W4, W5, EG, each RT, and HP are all absent, SG is a single bond.