US 11,865,344 B2
Neurostimulation titration process via adaptive parametric modification
Imad Libbus, St. Paul, MN (US); Bruce H. KenKnight, Maple Grove, MN (US); Badri Amurthur, Los Gatos, CA (US); and Scott R. Stubbs, Maple Grove, MN (US)
Assigned to LivaNova USA, Inc., Houston, TX (US)
Filed by LivaNova USA, Inc., Houston, TX (US)
Filed on Dec. 5, 2019, as Appl. No. 16/705,043.
Application 16/705,043 is a continuation of application No. 15/360,188, filed on Nov. 23, 2016, granted, now 10,500,398.
Application 15/360,188 is a continuation of application No. 14/563,181, filed on Dec. 8, 2014, granted, now 9,504,832.
Claims priority of provisional application 62/078,600, filed on Nov. 12, 2014.
Prior Publication US 2020/0108256 A1, Apr. 9, 2020
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); G16H 40/63 (2018.01); A61N 1/37 (2006.01); G16Z 99/00 (2019.01); G16H 40/20 (2018.01); G16H 20/30 (2018.01); A61B 5/349 (2021.01); A61N 1/372 (2006.01); G16H 20/40 (2018.01)
CPC A61N 1/36139 (2013.01) [A61B 5/349 (2021.01); A61N 1/0551 (2013.01); A61N 1/3615 (2013.01); A61N 1/36114 (2013.01); A61N 1/36132 (2013.01); A61N 1/36167 (2013.01); A61N 1/3702 (2013.01); A61N 1/37223 (2013.01); A61N 1/37235 (2013.01); G16H 20/30 (2018.01); G16H 20/40 (2018.01); G16H 40/20 (2018.01); G16H 40/63 (2018.01); G16Z 99/00 (2019.02)] 20 Claims
OG exemplary drawing
 
1. A method of operating an implantable medical device (IMD) comprising a neurostimulator coupled to an electrode assembly, comprising:
delivering neurostimulation to a patient by the IMD, the neurostimulation comprising a plurality of stimulation parameters;
automatically increasing an intensity of the neurostimulation by an increment by modifying at least one of the stimulation parameters and delivering the neurostimulation according to the increased intensity over an acclimation interval, the acclimation interval comprising a period of time;
repeating automatically increasing the intensity and delivering the neurostimulation according to the increased intensity;
receiving, from an external control device, a first input from the patient indicating intolerance to the neurostimulation;
in response to receiving the first input from the patient, modifying at least one of the stimulation parameters to decrease the intensity of the neurostimulation;
subsequent to modifying the at least one of the stimulation parameters to decrease the intensity of the neurostimulation, receiving, from the external control device, a plurality of additional inputs from the patient indicating intolerance to the neurostimulation; in response to receiving the plurality of additional inputs from the patient, increasing the acclimation interval;
determining that the acclimation interval has reached a maximum acclimation interval; and
in response to determining that the acclimation interval has reached the maximum acclimation interval, modifying at least one different stimulation parameter to decrease the intensity of the neurostimulation.