	US 11,865,184 B2
	Method of targeting senescent cells
Valery Krizhanovsky, Rehovot (IL); and Yossi Ovadya, Rehovot (IL)
Assigned to YEDA RESEARCH AND DEVELOPMENT CO. LTD., Rehovot (IL)
Filed by YEDA RESEARCH AND DEVELOPMENT CO. LTD., Rehovot (IL)
Filed on Oct. 21, 2020, as Appl. No. 17/075,738.
Application 17/075,738 is a continuation of application No. 15/573,550, granted, now 10,849,985, previously published as PCT/IL2016/050535, filed on May 19, 2016.
Claims priority of provisional application 62/164,025, filed on May 20, 2015.
Prior Publication US 2021/0038740 A1, Feb. 11, 2021
Int. Cl. A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); C07K 16/18 (2006.01); C12N 15/113 (2010.01)

CPC A61K 47/6843 (2017.08) [A61K 45/06 (2013.01); A61K 47/6807 (2017.08); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); C07K 16/18 (2013.01); C12N 15/1137 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3513 (2013.01)]

2 Claims

1. A method of treating a pulmonary disease associated with cellular senescence in a subject in need, said method comprising administering a pharmaceutical agent to the subject, wherein said pharmaceutical agent is an antibody that binds specifically to a cell surface polypeptide set forth in SEQ ID NO: 29, wherein said cell is a senescent cell, wherein said a pulmonary disease is selected from idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (COPD), and wherein accumulation of senescent cells is observed in said disease associated with cellular senescence.