US 11,865,139 B2
Method of treating migraines and headaches
Ronald Kramer, Signal Hill, CA (US); and Alexandros Nikolaidis, Nea Kallikratia (GR)
Assigned to THERMOLIFE INTERNATIONAL, LLC, Signal Hill, CA (US)
Filed by ThermoLife International, LLC, Signal Hill, CA (US)
Filed on Jun. 8, 2022, as Appl. No. 17/835,805.
Application 17/835,805 is a continuation in part of application No. 17/670,383, filed on Feb. 11, 2022.
Application 17/670,383 is a continuation of application No. PCT/US2022/016231, filed on Feb. 11, 2022.
Application PCT/US2022/016231 is a continuation in part of application No. 17/525,841, filed on Nov. 12, 2021.
Claims priority of provisional application 63/232,852, filed on Aug. 13, 2021.
Claims priority of provisional application 63/180,039, filed on Apr. 26, 2021.
Claims priority of provisional application 63/148,523, filed on Feb. 11, 2021.
Claims priority of provisional application 63/148,517, filed on Feb. 11, 2021.
Claims priority of provisional application 63/113,114, filed on Nov. 12, 2020.
Prior Publication US 2022/0296638 A1, Sep. 22, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 33/06 (2006.01); A61P 25/06 (2006.01); A61K 33/30 (2006.01); A61K 33/24 (2019.01); A61K 31/375 (2006.01); A61K 31/194 (2006.01); A61K 9/00 (2006.01); A61K 33/26 (2006.01)
CPC A61K 33/06 (2013.01) [A61K 9/0053 (2013.01); A61K 31/194 (2013.01); A61K 31/375 (2013.01); A61K 33/24 (2013.01); A61K 33/26 (2013.01); A61K 33/30 (2013.01); A61P 25/06 (2018.01)] 26 Claims
 
1. A method of treating a headache in a subject, the method comprising administering to the subject an effective amount of an elemental metal and an effective amount of a source of nitrate anion, wherein the elemental metal is selected from elemental magnesium, elemental calcium, elemental zinc, or any combination thereof.