US 10,890,641 B2
System and method of robust quantitative susceptibility mapping
Yi Wang, New York, NY (US); Zhe Liu, New York, NY (US); Youngwook Kee, New York, NY (US); Alexey Dimov, New York, NY (US); Yan Wen, New York, NY (US); Jingwei Zhang, Woodside, NY (US); and Pascal Spincemaille, New York, NY (US)
Assigned to Cornell University, Ithaca, NY (US)
Filed by CORNELL UNIVERSITY, Ithaca, NY (US)
Filed on Apr. 3, 2018, as Appl. No. 15/943,753.
Claims priority of provisional application 62/482,864, filed on Apr. 7, 2017.
Prior Publication US 2018/0321347 A1, Nov. 8, 2018
Int. Cl. G06K 9/00 (2006.01); G01R 33/56 (2006.01); A61B 5/055 (2006.01); G01R 33/565 (2006.01); G01R 33/24 (2006.01); A61B 5/026 (2006.01); A61B 5/00 (2006.01); G01R 33/50 (2006.01); G01R 33/48 (2006.01); A61B 5/145 (2006.01)
CPC G01R 33/5608 (2013.01) [A61B 5/0042 (2013.01); A61B 5/0263 (2013.01); A61B 5/055 (2013.01); A61B 5/7203 (2013.01); G01R 33/24 (2013.01); G01R 33/56527 (2013.01); A61B 5/0035 (2013.01); A61B 5/14542 (2013.01); A61B 5/4082 (2013.01); A61B 5/4088 (2013.01); A61B 5/4504 (2013.01); A61B 5/4872 (2013.01); G01R 33/4828 (2013.01); G01R 33/50 (2013.01); G01R 33/5602 (2013.01); G01R 33/56536 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for generating one or more images of an object, the method comprising:
receiving magnetic resonance imaging (MRI) data obtained by a magnetic resonance scanner, wherein the MRI data is complex and comprises magnitude and phase information or real and imaginary information regarding tissue in the object, and Gaussian noise;
calculating a magnetic field experienced by the tissue in the object based on modeling the complex MRI data according to tissue composition;
identifying a region of interest in the tissue that has an approximately uniform susceptibility according to a characteristic feature, wherein the characteristic feature is low R2* value and the region of interest is determined by applying R2* thresholding and connectivity;
estimating a magnetic susceptibility distribution of the object based on the calculated magnetic field, wherein estimating the magnetic susceptibility distribution of the subject comprises:
determining a cost function, the cost function relating at least a data fidelity term associated with a likelihood function of the Gaussian noise in the MRI data, a first regularization term associated with a structure prior information, and a second regularization term associated with enforcing the approximately uniform susceptibility in the region of interest in the tissue; and
determining a magnetic susceptibility distribution based on minimizing the cost function; and
outputting, to a display device or to a storage device, one or more images of the object generated based on the determined magnetic susceptibility distribution.