US 10,890,584 B2
Devices for detecting analytes using thermal waves and related methods
Bart Robert Nicolaas Van Grinsven, Heerlen (NL); and Thomas Jan Cleij, Elsloo (NL)
Assigned to Academisch Ziekenhuis Maastricht, Maastricht (NL)
Appl. No. 15/776,324
Filed by Academisch Ziekenhuis Maastricht, Maastricht (NL); and Universiteit Maastricht, Maastricht (NL)
PCT Filed Nov. 3, 2016, PCT No. PCT/EP2016/076571
§ 371(c)(1), (2) Date May 15, 2018,
PCT Pub. No. WO2017/084885, PCT Pub. Date May 26, 2017.
Application 15/776,324 is a continuation of application No. 15/095,636, filed on Apr. 11, 2016, granted, now 10,139,407.
Claims priority of provisional application 62/314,461, filed on Mar. 29, 2016.
Claims priority of application No. 15194837 (EP), filed on Nov. 16, 2015; application No. 16162550 (EP), filed on Mar. 29, 2016; application No. 16162685 (EP), filed on Mar. 29, 2016; and application No. 16164636 (EP), filed on Apr. 11, 2016.
Prior Publication US 2018/0328924 A1, Nov. 15, 2018
Int. Cl. G01N 33/543 (2006.01); G01N 33/569 (2006.01); G01N 25/18 (2006.01); G01N 25/20 (2006.01); G01N 33/487 (2006.01)
CPC G01N 33/56911 (2013.01) [G01N 25/18 (2013.01); G01N 25/20 (2013.01); G01N 33/487 (2013.01); G01N 33/54373 (2013.01); G01N 2333/245 (2013.01); G01N 2333/31 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A device for detecting an analyte, the device comprising:
a substrate having a polymer material formed on a surface thereof, the polymer material formulated to bind to the analyte, wherein a heat transfer property of the polymer material is formulated to vary based on an amount of the analyte bound thereto;
a heat transfer element thermally coupled to a surface of the substrate opposite the polymer material;
a temperature modification device thermally coupled to the heat transfer element;
a controller configured to cause the temperature modification device to produce a thermal wave emanating from the heat transfer element;
a flow cell located and configured to pass a liquid over the polymer material of the substrate;
a temperature sensor configured to detect a temperature of the liquid passing over the polymer material; and
a processor configured to calculate a concentration of an analyte in the liquid based at least in part on a phase shift between the thermal wave at the heat transfer element and an attenuated thermal wave in the liquid.