US 10,889,843 B2
Corynebacterium sp. microorganisms having l-lysine-producing ability and l-lysine producing method using same
Hyo Jeong Byun, Gyeonggi-do (KR); Yoon Hee Chung, Seoul (KR); Hyung Joon Kim, Seoul (KR); Sun Young Lee, Gyeonggi-do (KR); Hyun Koo Nam, Gyeonggi-do (KR); Sun Mi Park, Seoul (KR); and Sang Mok Lee, Seoul (KR)
Assigned to CJ Cheiljedang Corporation, Seoul (KR)
Appl. No. 15/755,582
Filed by CJ Cheiljedang Corporation, Seoul (KR)
PCT Filed Jul. 27, 2016, PCT No. PCT/KR2016/008231
§ 371(c)(1), (2) Date Feb. 27, 2018,
PCT Pub. No. WO2017/034164, PCT Pub. Date Mar. 2, 2017.
Claims priority of application No. 10-2015-0120871 (KR), filed on Aug. 27, 2015.
Prior Publication US 2018/0258452 A1, Sep. 13, 2018
Int. Cl. C12P 13/08 (2006.01); C12N 1/21 (2006.01); C12N 15/77 (2006.01); C07K 14/34 (2006.01); C12N 9/10 (2006.01); C12N 9/12 (2006.01); C12N 9/02 (2006.01); C12N 9/88 (2006.01); C12R 1/15 (2006.01)
CPC C12P 13/08 (2013.01) [C07K 14/34 (2013.01); C12N 9/0008 (2013.01); C12N 9/0093 (2013.01); C12N 9/1096 (2013.01); C12N 9/12 (2013.01); C12N 9/88 (2013.01); C12N 15/77 (2013.01); C12R 1/15 (2013.01); C12Y 102/01011 (2013.01); C12Y 117/01 (2013.01); C12Y 206/01001 (2013.01); C12Y 207/02004 (2013.01); C12Y 401/0102 (2013.01); C12Y 402/01 (2013.01)] 6 Claims
 
1. A modified microorganism of the genus Corynebacterium, wherein a protein comprising the amino acid sequence of SEQ ID NO: 1 is inactivated; and having enhanced expression of one or more genes selected from the group consisting of aspB (aspartate aminotransferase-encoding gene) lysC (aspartate kinase-encoding gene), asd (aspartate semialdehyde dehydrogenase-encoding gene), dapA (dihydrodipicolinate synthase-encoding gene), dapB (dihydrodipicolinate reductase-encoding gene) and lysA (diaminodipimelate decarboxylase-encoding gene).