US 10,889,818 B2
Translocation and mutant ROS kinase in human non-small cell lung carcinoma
Ailan Guo, Burlington, MA (US); and Anthony Possemato, Worcester, MA (US)
Assigned to CELL SIGNALING TECHNOLOGY, INC., Danvers, MA (US)
Filed by Ailan Guo, Burlington, MA (US); and Anthony Possemato, Worcester, MA (US)
Filed on Sep. 14, 2012, as Appl. No. 13/616,107.
Application 13/616,107 is a division of application No. 12/218,834, filed on Jul. 18, 2008, granted, now 8,383,799.
Application 12/218,834 is a continuation of application No. PCT/US2007/001360, filed on Jan. 19, 2007.
Claims priority of provisional application 60/760,634, filed on Jan. 20, 2006.
Prior Publication US 2013/0059305 A1, Mar. 7, 2013
Int. Cl. C12N 15/113 (2010.01); C12N 9/12 (2006.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01); C07K 14/82 (2006.01); C07K 14/47 (2006.01); C12Q 1/6841 (2018.01)
CPC C12N 15/1137 (2013.01) [C07K 14/47 (2013.01); C07K 14/82 (2013.01); C12N 9/1205 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57423 (2013.01); G01N 33/57484 (2013.01); C07K 2319/00 (2013.01); C12N 2310/14 (2013.01); C12Q 1/6841 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/156 (2013.01)] 5 Claims
 
1. A composition, comprising
a biological sample of from a human having cancer, and
a nucleic acid reagent comprising a primer pair,
wherein the primer pair hybridizes to a polynucleotide encoding a Sodium-Dependent Phosphate Transporter Isoform NaPi-3b protein (SLC34A2)-Proto-Oncogene Tyrosine Protein Kinase ROS precursor (ROS) fusion polypeptide, and
wherein the polynucleotide comprises the nucleotide sequence of SEQ ID NO: 4.