US 10,889,665 B2
Process for functionalizing a biocompatible polymeric bead, the functionalized beads, and the beads produced thereby
Thomas Golobish, Monmouth Junction, NJ (US); Tamaz Guliashvili, Monmouth Junction, NJ (US); and Vincent Capponi, Monmouth Junction, NJ (US)
Assigned to CYTOSORBENTS, INC., Monmouth Junction, NJ (US)
Filed by CytoSorbents, Inc., Monmouth Junction, NJ (US)
Filed on May 10, 2019, as Appl. No. 16/408,977.
Claims priority of provisional application 62/671,665, filed on May 15, 2018.
Prior Publication US 2019/0352437 A1, Nov. 21, 2019
Int. Cl. C08F 212/36 (2006.01); C08F 8/08 (2006.01); C08F 212/08 (2006.01)
CPC C08F 8/08 (2013.01) [C08F 212/08 (2013.01); C08F 212/36 (2013.01); C08F 2500/24 (2013.01)] 4 Claims
1. A process for making a polymeric bead having an epoxide group with a biological molecule attached thereto on its surface, said polymeric beads comprising pores having an average diameter of less than 200 Angstroms, comprising simultaneously contacting a polymeric bead which comprises monomeric divinylbenzene and has pores having an average diameter of less than 200 Angstroms with acetic acid and hydrogen peroxide to form an epoxide group on the surface of said polymeric beads, and attaching a biological molecule to said epoxide group.