US 10,889,609 B2
Mannitol-based amphipathic compound and use thereof
Pil Seok Chae, Gyeonggi-do (KR); and Hazrat Hussain, Gyeonggi-do (KR)
Assigned to INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS, Gyeonggi-Do (KR)
Appl. No. 15/758,782
Filed by Industry-University Cooperation Foundation Hanyang University Erica Campus, Gyeonggi-do (KR)
PCT Filed Dec. 14, 2015, PCT No. PCT/KR2015/013688
§ 371(c)(1), (2) Date Mar. 9, 2018,
PCT Pub. No. WO2017/043703, PCT Pub. Date Mar. 16, 2017.
Claims priority of application No. 10-2015-0127586 (KR), filed on Sep. 9, 2015.
Prior Publication US 2019/0077822 A1, Mar. 14, 2019
Int. Cl. C07H 15/04 (2006.01); C07C 41/28 (2006.01); C07K 1/14 (2006.01); G01N 33/68 (2006.01); C07K 1/32 (2006.01); C07H 1/00 (2006.01)
CPC C07H 15/04 (2013.01) [C07C 41/28 (2013.01); C07H 1/00 (2013.01); C07K 1/14 (2013.01); C07K 1/145 (2013.01); C07K 1/32 (2013.01); G01N 33/68 (2013.01); G01N 33/6872 (2013.01); Y02P 20/55 (2015.11)] 7 Claims
 
1. A composition for extracting, solubilizing, stabilizing or crystallizing a membrane protein, or analyzing a structure of the membrane protein using an electron microscope, the composition comprising a compound represented by the following Formula 1:

OG Complex Work Unit Drawing
wherein R1 and R2 are each independently an unsubstituted C5-C20 alkyl group, a substituted or unsubstituted C5-C20 cycloalkyl group, or a substituted or unsubstituted C5-C20 aryl group; and
X1, X2, X3, and X4 are each independently a glucose or maltose,
whereby the composition is for extracting, solubilizing, stabilizing or crystallizing a membrane protein, or analyzing the structure of the membrane protein using the electron microscope.