US 10,889,567 B2
Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
Jian Lin, Acton, MA (US); Anna Ericsson, Shrewsbury, MA (US); Ann-Marie Campbell, Monroe, CT (US); Gary Gustafson, Ridgefield, CT (US); Zhongguo Wang, Lexington, MA (US); R. Bruce Diebold, Waltham, MA (US); Susan Ashwell, Carlisle, MA (US); David R. Lancia, Jr., Boston, MA (US); Justin Andrew Caravella, Cambridge, MA (US); and Wei Lu, Newton, MA (US)
Assigned to FORMA Therapeutics, Inc., Watertown, MA (US)
Filed by FORMA Therapeutics, Inc., Watertown, MA (US)
Filed on Dec. 12, 2019, as Appl. No. 16/712,951.
Application 16/712,951 is a continuation of application No. 16/290,240, filed on Mar. 1, 2019, granted, now 10,550,098.
Application 16/290,240 is a continuation of application No. 15/964,844, filed on Apr. 27, 2018, granted, now 10,414,752, issued on Sep. 17, 2019.
Application 15/964,844 is a continuation of application No. 15/452,256, filed on Mar. 7, 2017, abandoned.
Application 15/452,256 is a continuation of application No. 14/858,167, filed on Sep. 18, 2015, granted, now 9,834,539, issued on Dec. 5, 2017.
Claims priority of provisional application 62/150,812, filed on Apr. 21, 2015.
Claims priority of provisional application 62/128,089, filed on Mar. 4, 2015.
Claims priority of provisional application 62/053,006, filed on Sep. 19, 2014.
Prior Publication US 2020/0223822 A1, Jul. 16, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); A61P 35/00 (2006.01); A61K 31/47 (2006.01)
CPC C07D 401/12 (2013.01) [A61P 35/00 (2018.01); C07D 401/14 (2013.01); C07D 471/04 (2013.01); A61K 31/47 (2013.01)] 21 Claims
 
1. A method of preparing Compound I-13:

OG Complex Work Unit Drawing
wherein the method comprises steps of:
reacting Intermediate II-1 or a salt thereof and Intermediate III-1:

OG Complex Work Unit Drawing
to provide Compound I-13; and
preparing Intermediate II-1 or a salt thereof by contacting ((S)—N—((S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-2-methyl propane-2-sulfinamide:

OG Complex Work Unit Drawing
with a suitable acid to provide Intermediate II-1 or a salt thereof.