US 10,888,862 B2
Acceleration-primed valving system for centrifugal microfluidics
Gregory J. Kellogg, Cambridge, MA (US); David Doolan, Tullamore (IE); and Donal Cronin, Mallow (IE)
Assigned to Radisens Diagnostics Limited, (IE)
Filed by Radisens Diagnostics Limited, Cork (IE)
Filed on Nov. 19, 2018, as Appl. No. 16/194,637.
Application 16/194,637 is a continuation in part of application No. 14/649,654, granted, now 10,130,947, previously published as PCT/EP2013/075736, filed on Dec. 5, 2013.
Claims priority of provisional application 61/733,866, filed on Dec. 5, 2012.
Claims priority of application No. 12195761 (EP), filed on Dec. 5, 2012.
Prior Publication US 2019/0091686 A1, Mar. 28, 2019
Int. Cl. B01L 3/00 (2006.01)
CPC B01L 3/502738 (2013.01) [B01L 3/50273 (2013.01); B01L 2200/06 (2013.01); B01L 2200/0605 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0803 (2013.01); B01L 2300/087 (2013.01); B01L 2400/0406 (2013.01); B01L 2400/0409 (2013.01); B01L 2400/0688 (2013.01)] 15 Claims
OG exemplary drawing
1. A microfluidic system for processing biological samples comprising:
a holding chamber adapted for holding a fluid and to be rotated on a platform about a central axis, wherein the holding chamber is dimensioned to have an inner radial wall of radius (R1) and outer radial wall of radius (R2) from the central axis, said holding chamber comprising an outlet through which fluid flow is controlled by an acceleration-primed valve system, wherein the acceleration-primed valve system comprises a capillary valve and an outlet channel, the capillary valve comprising an innermost portion that is radially inward, (R3), of the outermost portion of the holding chamber, (R2), and wherein the capillary valve is primed by a force generated by a tangential acceleration of the platform, wherein the capillary valve is positioned such that upon rotating the platform about the central axis at any speed the capillary valve is innermost to a meniscus of the fluid within the holding chamber when under centrifugal force.