US 10,888,799 B2
Valve manifolds for simulated moving bed chromatography
Klaus Gebauer, Uppsala (SE); and Bjorn Markus Olovsson, Uppsala (SE)
Assigned to Cytiva Sweden AB, Uppsala (SE)
Appl. No. 15/534,540
Filed by Cytiva Sweden AB, Uppsala (SE)
PCT Filed Dec. 23, 2015, PCT No. PCT/EP2015/081179
§ 371(c)(1), (2) Date Jun. 9, 2017,
PCT Pub. No. WO2016/107809, PCT Pub. Date Jul. 7, 2016.
Claims priority of provisional application 62/098,605, filed on Dec. 31, 2014.
Prior Publication US 2017/0361245 A1, Dec. 21, 2017
Int. Cl. B01D 15/18 (2006.01); G01N 30/20 (2006.01); G01N 30/42 (2006.01); G01N 30/46 (2006.01); G01N 30/88 (2006.01)
CPC B01D 15/1842 (2013.01) [G01N 30/20 (2013.01); G01N 30/461 (2013.01); G01N 30/466 (2013.01); G01N 30/467 (2013.01); G01N 30/88 (2013.01); G01N 30/42 (2013.01); G01N 30/468 (2013.01); G01N 2030/205 (2013.01); G01N 2030/8881 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A device for chromatographic separations comprising:
a manifold comprising
a manifold body defining an elongate central duct, the central duct comprising a centrally-located closable duct valve providing selective fluid communication between a first portion of the central duct and an opposed second portion of the central duct,
a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold;
a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold;
wherein said manifold body further defines:
a first plurality of branch ducts and through ducts, each individual branch duct extending from the first portion of the central duct to an individual one of a through duct of the first plurality of connectors, each of the branch ducts of the first plurality of branch ducts comprising a closable access valve providing selectable fluid communication between a respective connector and the first portion of the central duct,
a second plurality of branch ducts and through ducts, each individual branch duct extending from the second portion of the central duct to an individual one of the through ducts of the second plurality of connectors, each of the branch ducts of the second plurality of branch ducts comprising a closable access valve providing selectable fluid communication between a respective connector and the second portion of the central duct;
first and second ports in fluid communication with the centrally-located closable duct valve wherein said first port communicates with said first portion of the central duct and said second port communicates with said second portion of said central duct, wherein one of said first and second ports is further positioned to communicate with said central duct at a location between the centrally-located closable duct valve and the first and second plurality of branch ducts, respectively; and wherein
a branch valve is positioned along each through duct of said first and second plurality of through ducts, the device further comprising:
a plurality of central duct valves, wherein a first portion of the central duct valves are positioned along the first portion of the central duct between successive branch ducts of the first plurality of branch ducts and a second portion of the central duct valves are positioned along the second portion of the central duct between successive branch ducts of the second plurality of branch ducts.