US 10,888,636 B2
Curable calcium phosphate compositions for use with porous structures and methods of using the same
Siddhesh Angle, Allston, MA (US); Michael Strunk, Exton, PA (US); Tak Lung Chang, Exton, PA (US); Bradford J. Coale, Chester, NJ (US); Greg Stebbins, Hoboken, NJ (US); and Imants Liepins, Asbury, NJ (US)
Assigned to ZIMMER KNEE CREATIONS, INC., Exton, PA (US)
Filed by ZIMMER KNEE CREATIONS, INC., Exton, PA (US)
Filed on Oct. 7, 2016, as Appl. No. 15/288,149.
Claims priority of provisional application 62/238,776, filed on Oct. 8, 2015.
Prior Publication US 2017/0100507 A1, Apr. 13, 2017
Int. Cl. A61L 27/20 (2006.01); A61L 27/46 (2006.01); A61L 27/56 (2006.01); A61L 27/42 (2006.01); A61L 27/12 (2006.01); A61L 27/30 (2006.01); A61L 27/36 (2006.01)
CPC A61L 27/20 (2013.01) [A61L 27/12 (2013.01); A61L 27/306 (2013.01); A61L 27/365 (2013.01); A61L 27/3608 (2013.01); A61L 27/3616 (2013.01); A61L 27/422 (2013.01); A61L 27/427 (2013.01); A61L 27/46 (2013.01); A61L 27/56 (2013.01); A61L 2400/06 (2013.01); A61L 2400/08 (2013.01); A61L 2430/02 (2013.01); A61L 2430/24 (2013.01)] 17 Claims
 
1. An apparatus comprising:
a porous metal structure comprising
a porous substrate comprising a plurality of ligaments that define pores of the porous substrate, and
a biocompatible metal coating on the plurality of ligaments of the porous substrate; and
a curable calcium phosphate composition or a cured product thereof at least partially in contact with the porous metal structure and injection-perfused into the pore space of the porous metal structure to a depth of greater than 6 mm from a surface of the porous metal structure and greater than 10 pore diameters from the surface of the porous metal structure, the curable calcium phosphate composition comprising
calcium phosphate,
a perfusion modifier, wherein the perfusion modifier is 0.5 wt % to 5 wt % of the curable calcium phosphate composition, wherein the perfusion modifier is methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, a salt thereof or a combination thereof, and
a physiologically acceptable fluid.