US 10,888,630 B2
Magnetic nanoparticles functionalized with catechol, production and use thereof
Giovanni Baldi, Montelupo Fiorentino (IT); Costanza Ravagli, Sesto Fiorentino (IT); Mauro Comes Franchini, San Lazzaro di Savena (IT); Mario Milco D'Elios, Empoli (IT); Marisa Benagiano, Rome (IT); and Marco Bitossi, Montelupo Fiorentino (IT)
Assigned to COLOROBBIA ITALIA S.P.A., Sovigliana Vinci (IT)
Appl. No. 15/110,189
Filed by COLOROBBIA ITALIA S.P.A., Sovigliana Vinci (IT)
PCT Filed Jan. 7, 2015, PCT No. PCT/IB2015/050122
§ 371(c)(1), (2) Date Jul. 7, 2016,
PCT Pub. No. WO2015/104664, PCT Pub. Date Jul. 16, 2015.
Claims priority of application No. FI2014A0003 (IT), filed on Jan. 7, 2014.
Prior Publication US 2016/0331850 A1, Nov. 17, 2016
Int. Cl. A61K 9/00 (2006.01); A61K 49/18 (2006.01); H01F 1/00 (2006.01); A61K 9/107 (2006.01); A61K 9/20 (2006.01); A61K 9/50 (2006.01); A61K 41/00 (2020.01)
CPC A61K 49/186 (2013.01) [A61K 9/1075 (2013.01); A61K 9/20 (2013.01); A61K 9/5031 (2013.01); A61K 9/5089 (2013.01); A61K 41/0052 (2013.01); A61K 49/1857 (2013.01); H01F 1/0054 (2013.01); H01F 1/0063 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A human immune system cell containing a construct, said construct comprising:
a structural center comprising a clustered plurality of magnetite nanoparticles, wherein the surface of each of the plurality of nanoparticles in the cluster is functionalized with catechol to provide hydrophobic reactivity to said clustered plurality of nanoparticles, and
a biocompatible polymeric matrix encapsulating the structural center, wherein a molecule having therapeutic action is optionally dispersed in said biocompatible polymeric matrix.