US 10,888,570 B2
Spironolactone aqueous compositions
Anthony Pipho, Winterville, NC (US); and Michael Paul DeHart, Winterville, NC (US)
Assigned to CMP DEVELOPMENT LLC, Farmville, NC (US)
Filed by CMP DEVELOPMENT LLC, Farmville, NC (US)
Filed on May 19, 2020, as Appl. No. 16/878,092.
Application 16/878,092 is a continuation of application No. 16/823,604, filed on Mar. 19, 2020, granted, now 10,660,907.
Application 16/823,604 is a continuation of application No. 16/682,477, filed on Nov. 13, 2019, granted, now 10,624,906, issued on Apr. 21, 2020.
Application 16/682,477 is a continuation of application No. 15/665,014, filed on Jul. 31, 2017, granted, now 10,493,083, issued on Dec. 3, 2019.
Application 15/665,014 is a continuation of application No. 15/337,559, filed on Oct. 28, 2016, granted, now 9,757,394, issued on Sep. 12, 2017.
Claims priority of provisional application 62/495,583, filed on Oct. 30, 2015.
Prior Publication US 2020/0276212 A1, Sep. 3, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/585 (2006.01); A61K 47/36 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 47/24 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/02 (2006.01); A61K 9/10 (2006.01)
CPC A61K 31/585 (2013.01) [A61K 9/0053 (2013.01); A61K 9/0095 (2013.01); A61K 9/20 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/24 (2013.01); A61K 47/36 (2013.01); A61K 9/10 (2013.01)] 20 Claims
 
1. A ready-to-use liquid formulation, comprising:
(a) about 0.20% w/v to about 1.0% w/v of spironolactone;
(b) from about 0.18% w/v to about 0.36% w/v of a xanthan gum;
(c) a pharmaceutically acceptable excipient; and
(d) a sufficient amount of a water vehicle;
wherein the formulation exhibits a content uniformity of about 100% labeled content after shaking the formulation for about 10 seconds.