US 10,888,548 B2
Anti-dandruff compositions comprising a spirofuranone lactam tetramic acid derivative
Russell Greig Kerr, Charlottetown (CA); David Patrick Overy, Carleton Place (CA); and Fabrice Berrué, Halifax (CA)
Assigned to Croda International Plc, (GB)
Appl. No. 15/580,017
Filed by Croda International PLC, Yorkshire (GB)
PCT Filed Jun. 8, 2016, PCT No. PCT/GB2016/051681
§ 371(c)(1), (2) Date Dec. 6, 2017,
PCT Pub. No. WO2016/198850, PCT Pub. Date Dec. 15, 2016.
Claims priority of application No. 1509849.4 (GB), filed on Jun. 8, 2015.
Prior Publication US 2018/0177762 A1, Jun. 28, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/407 (2006.01); A61K 31/336 (2006.01); A61Q 5/00 (2006.01); A61K 31/4025 (2006.01); A61K 8/49 (2006.01); C12P 17/16 (2006.01); C12P 17/18 (2006.01); C12R 1/645 (2006.01)
CPC A61K 31/407 (2013.01) [A61K 8/4973 (2013.01); A61K 31/336 (2013.01); A61K 31/4025 (2013.01); A61Q 5/006 (2013.01); C12P 17/162 (2013.01); C12P 17/182 (2013.01); C12R 1/645 (2013.01)] 17 Claims
 
1. An anti-dandruff composition comprising an effective amount of:
at least one compound selected from the group consisting of pseurotin A, pseurotin A1, pseurotin A2, pseurotin B, pseurotin C, pseurotin E, pseurotin D, pseurotin F1, pseurotin F2, asaspirenen, and synerazol; and
at least one meroterpene represented by formula (I):

OG Complex Work Unit Drawing
wherein:
R1 represents hydrogen and R2 represents chlorine, or R1 and R2 together represent a single bond to form an epoxide ring;
R3 represents hydrogen or hydroxyl;
R4 represents a hydroxyl, oxygen, or —OC(O)—[CH═CH—]nR5 group wherein R5 represents a C2-C4 alcohol or diol, a C2-C4 optionally substituted epoxide, or a carboxyl group; and
n represents an integer in the range from 1 to 3.