US 10,888,542 B2
Aminocarbonylcarbamate compounds
Young-Soon Kang, Daejeon (KR); Jin-Yong Chung, Daejeon (KR); Cheol-Young Maeng, Daejeon (KR); Han-Ju Yi, Daejeon (KR); Ki-Ho Lee, Daejeon (KR); Joon Heo, Daejeon (KR); Eun-Hee Chae, Daejeon (KR); and Yu-Jin Shin, Daejeon (KR)
Assigned to SK BIOPHARMACEUTICALS CO., LTD., Gyeonggi-do (KR)
Filed by SK BIOPHARMACEUTICALS CO., LTD., Gyeonggi-do (KR)
Filed on Oct. 16, 2019, as Appl. No. 16/654,168.
Application 15/195,326 is a division of application No. 14/633,388, filed on Feb. 27, 2015, granted, now 9,403,761, issued on Aug. 2, 2016.
Application 16/654,168 is a continuation in part of application No. 16/395,422, filed on Apr. 26, 2019, granted, now 10,485,781.
Application 16/395,422 is a continuation of application No. 15/805,293, filed on Nov. 7, 2017, granted, now 10,314,808, issued on Jun. 11, 2019.
Application 15/805,293 is a continuation of application No. 15/195,326, filed on Jun. 28, 2016, granted, now 9,833,432, issued on Dec. 5, 2017.
Claims priority of provisional application 61/946,142, filed on Feb. 28, 2014.
Prior Publication US 2020/0046674 A1, Feb. 13, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/325 (2006.01); C07C 275/60 (2006.01); A61K 9/00 (2006.01); A61K 31/27 (2006.01); A61P 25/00 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/325 (2013.01) [A61K 9/0053 (2013.01); A61K 31/27 (2013.01); A61K 45/06 (2013.01); A61P 25/00 (2018.01); C07C 275/60 (2013.01)] 20 Claims
1. A method for treating dopamine reuptake-related diseases or promoting smoking cessation comprising:
administering to a mammal in need thereof a therapeutically effective amount of a compound of Formula (I) or pharmaceutically acceptable salt thereof,

OG Complex Work Unit Drawing
X is independently halo, alkyl, alkoxy or nitro;m is 0, 1, 2, 3 or 4n is 1 or 2;R1 and R2 are independently H— or alkyl;R3 is H—, alkyl or aralkyl; andR4 is H— or aryl,
wherein at least one of R1, R2, R3 and R4 is not H—,
wherein the dopamine reuptake-related disease is selected from the group consisting of fatigue, obesity, narcolepsy, fibromyalgia, cataplexy, drug addiction, sexual dysfunction, restless legs syndrome, bipolar disorder, depression, excessive daytime sleepiness, obsessive-compulsive disorder, and binge eating disorder.