US 10,888,267 B2
Method of treating sleep disordered breathing
Mark A. Christopherson, Golden Valley, MN (US); Quan Ni, Golden Valley, MN (US); Timothy P. Herbert, Golden Valley, MN (US); and John Rondoni, Golden Valley, MN (US)
Assigned to Inspire Medical Systems, Inc., Golden Valley, MN (US)
Filed by Inspire Medical Systems, Inc., Golden Valley, MN (US)
Filed on Aug. 17, 2016, as Appl. No. 15/239,057.
Application 14/597,422 is a division of application No. 13/130,287, granted, now 8,938,299, issued on Jan. 20, 2015, previously published as PCT/US2009/065165, filed on Nov. 19, 2009.
Application 15/239,057 is a continuation of application No. 14/597,422, filed on Jan. 15, 2015, abandoned.
Claims priority of provisional application 61/116,149, filed on Nov. 19, 2008.
Prior Publication US 2017/0128002 A1, May 11, 2017
Prior Publication US 2020/0146620 A9, May 14, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 5/08 (2006.01); A61N 1/36 (2006.01); A61B 5/0205 (2006.01); A61B 5/145 (2006.01); A61B 5/053 (2006.01); A61B 5/024 (2006.01)
CPC A61B 5/4818 (2013.01) [A61B 5/0205 (2013.01); A61B 5/0538 (2013.01); A61B 5/0803 (2013.01); A61B 5/0809 (2013.01); A61B 5/14542 (2013.01); A61B 5/4836 (2013.01); A61B 5/686 (2013.01); A61B 5/7282 (2013.01); A61N 1/3601 (2013.01); A61B 5/024 (2013.01); A61B 5/02405 (2013.01); A61B 5/053 (2013.01); A61B 2562/0214 (2013.01); A61B 2562/0247 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A method comprising:
applying, during a sleep period, electrical stimulation therapy via an implantable non-cardiac pulse generator and a non-cardiac electrode relative to a hypoglossal nerve to treat obstructive sleep apnea via at least tongue protrusion; and
assessing, via the non-cardiac pulse generator and at least during the sleep period, an effectiveness of the electrical stimulation therapy in relation to a level of the electrical stimulation therapy applied via the non-cardiac pulse generator in treating obstructive sleep apnea.
 
14. A method comprising:
applying, during a sleep period, electrical stimulation therapy via an implantable non-cardiac pulse generator and a non-cardiac electrode relative to a hypoglossal nerve to treat obstructive sleep apnea via at least tongue protrusion; and
continually assessing, via the non-cardiac pulse generator and at least during the sleep period, an effectiveness of the electrical stimulation therapy in relation to a level of the electrical stimulation therapy applied via the non-cardiac pulse generator to treat obstructive sleep apnea while maintaining application of the electrical stimulation therapy,
wherein the continual assessing, during the sleep period, the effectiveness of the electrical stimulation therapy in relation to the level of the electrical stimulation therapy to treat obstructive sleep apnea comprises determining respiratory information via acoustically sensing cardiac activity.
 
15. A method comprising:
applying, during a sleep period, electrical stimulation therapy via an implantable non-cardiac pulse generator and a non-cardiac electrode relative to a hypoglossal nerve to treat obstructive sleep apnea via at least tongue protrusion; and
assessing, via the non-cardiac pulse generator and at least during the sleep period, an effectiveness of the electrical stimulation therapy in relation to a level of the electrical stimulation therapy applied via the non-cardiac pulse generator,
wherein assessing the effectiveness of the electrical stimulation therapy in relation to the level of electrical stimulation therapy comprises:
counting a number of apnea events based on a heart rate.
 
16. A method comprising:
applying, during a sleep period, an electrical stimulation signal from an implantable non-cardiac pulse generator through at least one electrode to a hypoglossal nerve to stimulate at least one upper-airway patency-related muscle to increase upper airway patency at least until a number of obstructive sleep apnea events changes from a first level to a second level as assessed via the implantable non-cardiac pulse generator; and
continually assessing an effectiveness of the electrical stimulation signal as the number of obstructive sleep apnea events during the sleep period while applying the electrical stimulation signal.