US 12,191,005 B2
Radiology-based risk assessment for biopsy-based scores
Reinhold Wimberger-Friedl, Waalre (NL); Pedro Jorge Da Silva Rodrigues, Veldhoven (NL); and Vanda Lucia De Carvalho Vittorino De Almeida, Veldhoven (NL)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 17/625,105
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Jul. 22, 2020, PCT No. PCT/EP2020/070604
§ 371(c)(1), (2) Date Jan. 6, 2022,
PCT Pub. No. WO2021/013858, PCT Pub. Date Jan. 28, 2021.
Claims priority of application No. 19187572 (EP), filed on Jul. 22, 2019.
Prior Publication US 2022/0262465 A1, Aug. 18, 2022
Int. Cl. G16H 50/20 (2018.01); G16H 10/40 (2018.01); G16H 30/40 (2018.01)
CPC G16H 10/40 (2018.01) [G16H 30/40 (2018.01); G16H 50/20 (2018.01); G06T 2207/10081 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/10104 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A computer-implemented method for determining representativeness of a pathology score to a tumor, the method comprising:
analyzing a radiological image of a tumor to calculate a value indicative of tumor activity at each of a plurality of locations in the tumor;
determining whether each calculated value at each of the plurality of locations in the tumor is above a predetermined threshold to identify the total number of calculated values above the predetermined threshold;
calculating a heterogeneity score for the tumor, wherein the heterogeneity score is calculated based on a volume fraction of the tumor having a value indicative of tumor activity above the predetermined threshold, and thus wherein the heterogeneity score is calculated by dividing the total number of calculated values above the predetermined threshold by a total number of locations in the tumor for which a calculated value was determined; and
calculating a probability of a biopsy sample obtained from the tumor having a value of tumor activity above the predetermined threshold, wherein the probability is calculated based on the heterogeneity score and a volume of the biopsy sample.