utilizing one or more computers configured to execute specific program instructions for,

retrieving patient specific image data;

creating a 3D reconstruction of a vessel of interest from the patient specific image data, wherein the vessel of interest represents a subset of a coronary tree that includes a lesion;

determining boundary conditions that include inlet conditions that represent a set of velocity profiles, at a proximal side of the 3D reconstruction, over the multiple moments in time along at least the portion of the cardiac cycle;

calculating at least one of pressure parameters or anatomical parameters based at least in part on a portion of the 3D reconstruction that includes the lesion and the set of velocity profiles;

calculating a wall shear stress (WSS) vectors, based on the 3D reconstruction, at corresponding surface elements for a segment of a surface of the vessel that includes the lesion;

calculating a WSS descriptor based on a divergence of the WSS vectors, the WSS descriptor including a topological shear variation index (TSVI) representing an amount of variation in contraction or expansion applied at surface elements within the segment during at least a portion of a cardiac cycle; and

calculating a myocardial infarction (MI) index based on the WSS descriptor and the at least one of the pressure or anatomical parameters, the MI index representing a likelihood that the lesion will result in an MI.