US 12,188,898 B2
Non-enzymatic electrochemical sensor for measuring analytes
Jeff T. Suri, Fallbrook, CA (US)
Assigned to TERUMO KABUSHIKI KAISHA, Tokyo (JP)
Filed by TERUMO KABUSHIKI KAISHA, Tokyo (JP)
Filed on Sep. 27, 2023, as Appl. No. 18/475,237.
Application 18/475,237 is a division of application No. 16/931,279, filed on Jul. 16, 2020, abandoned.
Application 16/931,279 is a division of application No. 15/731,057, granted, now 10,761,053, issued on Sep. 1, 2020, previously published as PCT/US2015/027250, filed on Apr. 23, 2015.
Claims priority of provisional application 61/983,188, filed on Apr. 23, 2014.
Prior Publication US 2024/0019396 A1, Jan. 18, 2024
Int. Cl. C07F 5/02 (2006.01); G01N 27/416 (2006.01); G01N 33/487 (2006.01); G01N 33/66 (2006.01); G01N 33/68 (2006.01); G01N 33/94 (2006.01)
CPC G01N 27/4168 (2013.01) [C07F 5/025 (2013.01); G01N 27/4161 (2013.01); G01N 33/48707 (2013.01); G01N 33/66 (2013.01); G01N 33/6812 (2013.01); G01N 33/9413 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A composition comprising:
boronic acid-based synthetic redox-active receptors that can electrochemically sense a target analyte in a sample solution, and
a salt selected from the group consisting of:

OG Complex Work Unit Chemistry
where:
X− is an anion;
R and R′ are independently —(CH2)p—R1;
R1 is C1-C6 alkyl-B(OR2)(OR3), aryl-B(OR2)(OR3), heteroaryl-B(OR2)(OR3), or heterocyclyl-B(OR2)(OR3);
R2 and R3 are independently H, C1-C6 alkyl or R2 and R3 can combine with the B atom to form a ring system;
L and L′ are independently H, halogen, OH, CN, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkylthio, arylthio, alkoxy, aryloxy, —COOR4, NH2, —C(O)N(H)—(CH2)p—N(H)C(O)—R4, —C(O)NH(R4), or —N(H)C(O)R4,
R4 is independently at each occurrence H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, heterocyclyl, or cycloalkyl;
n is 2, 3, 4, 5, or 6; and
p is independently 0, 1, 2, 3, 4, 5, or 6.