US 12,188,869 B2
Light detection devices with protective liner and methods related to same
Xiuyu Cai, San Diego, CA (US); Joseph Francis Pinto, Solana Beach, CA (US); Thomas A. Baker, San Diego, CA (US); and Tracy Helen Fung, San Mateo, CA (US)
Assigned to ILLUMINA, INC., San Diego, CA (US)
Filed by Illumina, Inc., San Diego, CA (US)
Filed on Sep. 11, 2023, as Appl. No. 18/464,624.
Application 18/464,624 is a continuation of application No. 18/145,105, filed on Dec. 22, 2022, granted, now 11,781,985.
Application 18/145,105 is a continuation of application No. 17/190,094, filed on Mar. 2, 2021, granted, now 11,543,352, issued on Jan. 3, 2023.
Application 17/190,094 is a continuation of application No. 16/216,014, filed on Dec. 11, 2018, granted, now 10,955,343, issued on Mar. 23, 2021.
Claims priority of provisional application 62/609,889, filed on Dec. 22, 2017.
Claims priority of application No. 2020612 (NL), filed on Mar. 19, 2018.
Prior Publication US 2023/0417675 A1, Dec. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/64 (2006.01); B01L 3/00 (2006.01); G01J 1/44 (2006.01); G01N 21/05 (2006.01); G01N 33/58 (2006.01); G02B 6/42 (2006.01); H01L 27/144 (2006.01); H01L 27/146 (2006.01); H01L 31/02 (2006.01); H01L 31/0216 (2014.01); H01L 31/0232 (2014.01)
CPC G01N 21/6428 (2013.01) [B01L 3/502715 (2013.01); B01L 3/5085 (2013.01); B01L 3/50853 (2013.01); G01J 1/44 (2013.01); G01N 21/6454 (2013.01); G01N 33/582 (2013.01); G02B 6/4214 (2013.01); H01L 27/1446 (2013.01); H01L 27/14609 (2013.01); H01L 27/14623 (2013.01); H01L 27/14629 (2013.01); H01L 31/02019 (2013.01); H01L 31/02164 (2013.01); H01L 31/02165 (2013.01); H01L 31/02327 (2013.01); G01N 21/05 (2013.01); G01N 2021/6439 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A device, comprising:
a reaction structure comprising a plurality of reaction sites; and
a device base positioned beneath the reaction structure, wherein the device base comprises:
a plurality of light sensors;
a plurality of device circuits electrically coupled to the light sensors to transmit data signals based on photons detected by the light sensors;
a plurality of light guides wherein each light comprises an input region configured to receive excitation light and light emissions from at least one reaction site of the plurality of reaction sites, the light guides extending into the device base from the input regions toward at least one light sensor of the plurality of light sensors, said light guides comprising at least one filter material that filters at least some of the excitation light and permits at least some of the light emissions to pass to the at least one light sensor;
a protection layer extending about each light guide of the plurality of light guides, wherein the protection layer is chemically inert with respect to a reaction solution disposed over the reaction structure; and
a shield layer interposed between adjacent input regions to block the excitation light and the light emissions incident on the shield layer.