	US 12,188,080 B2
	Compositions and methods for isolation of cell-free DNA
Jeffrey Perry, Ann Arbor, MI (US)
Assigned to Enumera Molecular, Inc., Ann Arbor, MI (US)
Filed by Enumera Molecular, Inc., Ann Arbor, MI (US)
Filed on Apr. 19, 2023, as Appl. No. 18/303,536.
Application 18/303,536 is a division of application No. 17/507,373, filed on Oct. 21, 2021, granted, now 11,667,955.
Application 17/507,373 is a continuation of application No. PCT/US2021/051355, filed on Sep. 21, 2021.
Claims priority of provisional application 63/081,308, filed on Sep. 21, 2020.
Prior Publication US 2023/0272455 A1, Aug. 31, 2023
Int. Cl. C12Q 1/68 (2018.01); C12Q 1/6806 (2018.01); C12Q 1/6834 (2018.01)

CPC C12Q 1/6806 (2013.01) [C12Q 1/6834 (2013.01); C12Q 2537/16 (2013.01); C12Q 2600/16 (2013.01)]

14 Claims

1. A composition comprising a solution comprising:

a) antibody-DNA complexes that comprise:

i) cell-free DNA from a blood product sample from a human subject, and

ii) an exogenous anti-double-stranded DNA (anti-dsDNA) antibody that has reactivity to both single-stranded and double-stranded DNA.