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1. A mutant of β glucuronidase, wherein, in an amino acid sequence of Escherichia coli β glucuronidase, methionine at position 516 is substituted with lysine, and tyrosine at position 517 is substituted with a tryptophan, and, in the amino acid sequence of Escherichia coli β glucuronidase, asparagine at position 27 is substituted with tyrosine, phenylalanine at position 51 is substituted with tyrosine, alanine at position 64 is substituted with valine, aspartic acid at position 185 is substituted with asparagine, isoleucine at position 349 is substituted with phenylalanine, glycine at position 368 is substituted with cysteine, asparagine at position 369 is substituted with serine, tyrosine at position 525 is substituted with phenylalanine, glycine at position 559 is substituted with serine, lysine at position 567 is substituted with arginine, phenylalanine at position 582 is substituted with tyrosine, glutamine at position 585 is substituted with histidine, and glycine at position 601 is substituted with aspartic acid.
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