US 12,187,997 B2
Integrated human organ-on-chip microphysiological systems
Donald E. Ingber, Boston, MA (US); Anthony M. Bahinski, Wilmington, DE (US); Robert Cunningham, Cohasset, MA (US); Josue A. Goss, Somerville, MA (US); Geraldine A. Hamilton, Cambridge, MA (US); Christopher David Hinojosa, Cambridge, MA (US); Daniel Levner, Boston, MA (US); and Kevin Kit Parker, Waitham, MA (US)
Assigned to President and Fellows of Harvard College, Cambridge, MA (US)
Filed by President and Fellows of Harvard College, Cambridge, MA (US)
Filed on Jun. 30, 2023, as Appl. No. 18/346,165.
Application 18/346,165 is a continuation of application No. 17/146,264, filed on Jan. 11, 2021, granted, now 11,773,359.
Application 17/146,264 is a continuation of application No. 16/134,746, filed on Sep. 18, 2018, granted, now 10,954,482, issued on Mar. 23, 2021.
Application 16/134,746 is a continuation of application No. 14/928,039, filed on Oct. 30, 2015, abandoned.
Application 14/928,039 is a continuation of application No. 14/362,841, granted, now 9,725,687, issued on Aug. 8, 2017, previously published as PCT/US2012/068725, filed on Dec. 10, 2012.
Claims priority of provisional application 61/569,004, filed on Dec. 9, 2011.
Prior Publication US 2023/0348831 A1, Nov. 2, 2023
Int. Cl. C12M 3/06 (2006.01); A01N 1/02 (2006.01); B01L 3/00 (2006.01); B01L 9/00 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12M 1/42 (2006.01); C12M 3/00 (2006.01); G01N 33/50 (2006.01)
CPC C12M 23/16 (2013.01) [A01N 1/02 (2013.01); B01L 3/502715 (2013.01); B01L 9/52 (2013.01); C12M 21/08 (2013.01); C12M 23/42 (2013.01); C12M 29/10 (2013.01); C12M 35/04 (2013.01); C12M 35/08 (2013.01); C12M 41/00 (2013.01); G01N 33/5082 (2013.01); G01N 33/5088 (2013.01); A01N 1/021 (2013.01); A01N 1/0247 (2013.01); A01N 1/0273 (2013.01); B01L 3/5027 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/0689 (2013.01); B01L 2200/146 (2013.01); B01L 2200/147 (2013.01); B01L 2300/044 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/123 (2013.01); B01L 2300/18 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0622 (2013.01); B01L 2400/0644 (2013.01); C12M 41/12 (2013.01); C12M 41/46 (2013.01); G01N 33/5005 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A device, comprising Sertoli and Leydig cells on a first side of a membrane, and endothelial cells on a second side of said membrane.