US 12,187,848 B2
Compositions and methods for cellular delivery
Ellen M. Sletten, Los Angeles, CA (US); Daniel A. Estabrook, Los Angeles, CA (US); and John O. Chapman, Auburn, AL (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 17/612,931
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed May 20, 2020, PCT No. PCT/US2020/033730
§ 371(c)(1), (2) Date Nov. 19, 2021,
PCT Pub. No. WO2020/236894, PCT Pub. Date Nov. 26, 2020.
Claims priority of provisional application 62/850,514, filed on May 20, 2019.
Prior Publication US 2022/0227937 A1, Jul. 21, 2022
Int. Cl. A61K 47/59 (2017.01); C08G 73/02 (2006.01)
CPC C08G 73/0233 (2013.01) [A61K 47/59 (2017.08)] 20 Claims
 
1. A method of delivering a bioactive agent to an interior of a cell, comprising contacting the cell with a micelle comprising the bioactive agent and a polymer, wherein the bioactive agent is enmeshed by or encapsulated by the micelle and the polymer comprises repeat units represented by formula II:

OG Complex Work Unit Chemistry
wherein:
n is 30 or 90 and m is 10;
R1 is a group that imparts hydrophilic character to the polymer;
R2 is a group that imparts hydrophobic character to the polymer;
Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, and Y11 are each independently selected from NR3, O, S, Se, P, or C(R3)2;
each R3 is independently selected from hydrogen, alkyl, and aralkyl;
each R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is independently selected from hydrogen, alkyl, cycloalkyl, arylalkyl, heteroaryl, and heterocyclyl;
u is an integer from 1 to 10; and
v is an integer from 1 to 10.