US 12,187,846 B2
Degradable polyethylene glycol derivative
Hiroki Yoshioka, Kawasaki (JP); Masaki Kamiya, Kawasaki (JP); Yuji Yamamoto, Kawasaki (JP); Midori Hirai, Kawasaki (JP); Akiko Sasaki, Kawasaki (JP); Nobuhiro Nishiyama, Tokyo (JP); Makoto Matsui, Tokyo (JP); Hiroyasu Takemoto, Tokyo (JP); Kazuki Miyauchi, Tokyo (JP); Takahiro Nomoto, Tokyo (JP); and Keishiro Tomoda, Tokyo (JP)
Assigned to NOF Corporation, Tokyo (JP); and Tokyo Institute of Technology, Tokyo (JP)
Appl. No. 17/042,711
Filed by NOF CORPORATION, Tokyo (JP); and TOKYO INSTITUTE OF TECHNOLOGY, Tokyo (JP)
PCT Filed Mar. 29, 2019, PCT No. PCT/JP2019/014246
§ 371(c)(1), (2) Date Sep. 28, 2020,
PCT Pub. No. WO2019/189854, PCT Pub. Date Oct. 3, 2019.
Claims priority of application No. 2018-064305 (JP), filed on Mar. 29, 2018.
Prior Publication US 2021/0147624 A1, May 20, 2021
Int. Cl. C08G 65/333 (2006.01); A61K 47/60 (2017.01); A61K 47/62 (2017.01); A61K 47/65 (2017.01); C08G 65/325 (2006.01); C08L 71/02 (2006.01)
CPC C08G 65/33396 (2013.01) [A61K 47/65 (2017.08); C08G 65/325 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A degradable polyethylene glycol derivative represented by the following formula (1):

OG Complex Work Unit Chemistry
wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and
wherein the oligopeptide for Z is an oligopeptide having at least one hydrophobic neutral amino acid having a hydropathy index of not less than 2.5.