US 12,187,844 B2
Block copolymers of lactones and poly(propylene fumarate)
Matthew Becker, Stow, OH (US); James Wilson, Wolverhampton (GB); and Shannon Petersen, Youngwood, PA (US)
Assigned to The University of Akron, Akron, OH (US)
Appl. No. 16/483,208
Filed by THE UNIVERSITY OF AKRON, Akron, OH (US)
PCT Filed Mar. 20, 2018, PCT No. PCT/IB2018/051867
§ 371(c)(1), (2) Date Aug. 2, 2019,
PCT Pub. No. WO2018/142384, PCT Pub. Date Aug. 9, 2018.
Claims priority of provisional application 62/561,722, filed on Sep. 22, 2017.
Claims priority of provisional application 62/541,889, filed on Aug. 7, 2017.
Claims priority of provisional application 62/509,340, filed on May 22, 2017.
Claims priority of provisional application 62/500,777, filed on May 3, 2017.
Claims priority of provisional application 62/453,724, filed on Feb. 2, 2017.
Claims priority of provisional application 62/453,786, filed on Feb. 2, 2017.
Prior Publication US 2020/0231760 A1, Jul. 23, 2020
Int. Cl. C08G 63/52 (2006.01); B33Y 70/00 (2020.01); C08G 63/08 (2006.01); C08G 63/682 (2006.01); C08G 63/685 (2006.01); C08G 63/82 (2006.01); C08G 63/91 (2006.01); C08G 65/332 (2006.01); C08G 81/02 (2006.01); C08L 63/10 (2006.01); A61L 27/18 (2006.01); B33Y 80/00 (2015.01)
CPC C08G 63/52 (2013.01) [B33Y 70/00 (2014.12); C08G 63/08 (2013.01); C08G 63/682 (2013.01); C08G 63/6858 (2013.01); C08G 63/823 (2013.01); C08G 63/918 (2013.01); C08G 65/3322 (2013.01); C08G 81/027 (2013.01); C08L 63/10 (2013.01); A61L 27/18 (2013.01); B33Y 80/00 (2014.12)] 17 Claims
 
1. A diblock copolymer comprising a poly(lactone) segment having a first end comprising an end group comprising the residue of an initiating alcohol and a second end comprising a terminal hydroxyl group, and a poly(propylene fumarate) segment connected to the second end of said poly(lactone) segment and formed by ring-opening copolymerization of propylene oxide and maleic anhydride initiated by said terminal hydroxyl group on said poly(lactone) segment, followed by isomerization, said diblock copolymer having a polydispersity index (Ðm) of from about 1.1 to about 1.9.