wherein:

X¹ is a VHL binding motif having the formula —X^1A—X^1B—X^1C—;

X^1B is an L-hydroxyproline or an L-fluorohydroxyproline;

X^1A is selected from the group consisting of L-Tle, L-bMe-Ile, L-Tle-Tria, NMe-L-Tle-Tria, L-Tle-Tria-CyP, L-Val, L-Ala, L-Abu, L-Pen, L-Cha, L-Cpa, L-Cba, L-bMe2AllylGly, L-AdaGly and L-ThpGly;

X^1C is selected from the group consisting of D-MTPG, D-BiPhe, D-Ala, Aib, D-Bta, L-Bta, D-bMtpg, L-bMtpg, D-MtPhe, L-BiPhe, L-Tyr(O-Me), D-bBiPhe, D-bRMeBiPhe, D-bSMeBiPhe, D-Phe(4Br), D-Phe(4Cl), D-Phe(4F), D-Phe(4CN) and D-Phe(4I);

L^2C-L^2B-L^2A-X²-L^1A-L^1B-L^1C is selected from the group consisting of:

R^52A and R^52B are independently selected from the group consisting of hydrogen, C₁-C₄ alkyl, —CH₂-phenyl, —CH₂-biphenyl, —CH₂-pyridyl, —CH₂—CH₂—C(O)—NH₂, and —(CH₂)_n15—R¹¹¹ wherein n15 is an integer from 1 to 4, and R¹¹¹ is selected from the group consisting of —NH₂, N₃, and —C(O)—NH₂;

R⁵³ is selected from the group consisting of hydrogen, —C(O)NH₂, —[CH₂]_n16—NH₂—, and —[C(O)NH—CH₂]_n17—C(O) NH₂—, wherein each of n16 and n17 are independently an integer from 1 to 3;

R⁵⁴ is hydrogen or unsubstituted C₁-C₆ alkyl;

L¹⁰ is a bond, a peptide linker or a non-peptide linker; and

X³ comprises a target protein binding motif (TPBM).