US 12,187,812 B2
IBAT inhibitors for the treatment of liver diseases
Per-Göran Gillberg, Mölndal (SE); Hans Graffner, Helsingborg (SE); and Ingemar Starke, Gothenburg (SE)
Assigned to Albireo AB, Gothenburg (SE)
Filed by Albireo AB, Gothenburg (SE)
Filed on Oct. 25, 2022, as Appl. No. 17/973,133.
Application 17/973,133 is a continuation of application No. 17/206,925, filed on Mar. 19, 2021, granted, now 11,732,006.
Application 17/206,925 is a continuation of application No. 16/737,742, filed on Jan. 8, 2020, granted, now 10,981,952, issued on Apr. 20, 2021.
Application 16/737,742 is a continuation of application No. 15/069,199, filed on Mar. 14, 2016, granted, now 11,261,212, issued on Mar. 1, 2022.
Application 15/069,199 is a continuation of application No. 13/881,447, abandoned, previously published as PCT/SE2011/051335, filed on Nov. 8, 2011.
Claims priority of provisional application 61/410,957, filed on Nov. 8, 2010.
Claims priority of application No. 1051165-7 (SE), filed on Nov. 8, 2010.
Prior Publication US 2023/0109432 A1, Apr. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/55 (2006.01); A61K 31/554 (2006.01); A61K 31/575 (2006.01); A61K 38/05 (2006.01); A61P 35/00 (2006.01); C07K 5/062 (2006.01); C07K 5/065 (2006.01); A61K 38/00 (2006.01)
CPC C07K 5/06078 (2013.01) [A61K 31/55 (2013.01); A61K 31/554 (2013.01); A61K 31/575 (2013.01); A61K 38/05 (2013.01); A61P 35/00 (2018.01); C07K 5/06026 (2013.01); C07K 5/0606 (2013.01); A61K 38/00 (2013.01); A61K 2121/00 (2013.01)] 10 Claims
 
1. A method for treating a bile acid dependent disease, the method comprising orally administering to a subject in need of such treatment a therapeutically effective amount of an IBAT inhibitor, wherein the IBAT inhibitor is 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N—{(R)-α-[N—((S)-1-carboxypropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine, or a pharmaceutically acceptable salt thereof, wherein the bile acid dependent disease comprises a defect in the intrahepatic or extrahepatic biliary tree.