	US 12,187,804 B2
	Multivalent and multispecific 41BB-binding proteins
Brendan P. Eckelman, Encinitas, CA (US); John C. Timmer, San Diego, CA (US); Chelsie Macedo, La Jolla, CA (US); Kyle S. Jones, San Marcos, CA (US); Abrahim Hussain, La Jolla, CA (US); Amir S. Razai, La Jolla, CA (US); Bryan Becklund, San Diego, CA (US); Rajay Pandit, La Jolla, CA (US); Mike Kaplan, La Jolla, CA (US); Lucas Rascon, La Jolla, CA (US); and Quinn Deveraux, La Jolla, CA (US)
Assigned to Inhibrx Biosciences, Inc., La Jolla, CA (US)
Filed by Inhibrx Biosciences, Inc., La Jolla, CA (US)
Filed on Dec. 16, 2022, as Appl. No. 18/067,484.
Application 18/067,484 is a division of application No. 16/601,825, filed on Oct. 15, 2019, granted, now 11,566,078.
Application 16/601,825 is a division of application No. 15/404,016, filed on Jan. 11, 2017, granted, now 10,501,551, issued on Dec. 10, 2019.
Claims priority of provisional application 62/277,028, filed on Jan. 11, 2016.
Prior Publication US 2023/0416387 A1, Dec. 28, 2023
Int. Cl. C07K 16/28 (2006.01)

CPC C07K 16/2878 (2013.01) [C07K 16/2827 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/35 (2013.01); C07K 2317/52 (2013.01); C07K 2317/569 (2013.01); C07K 2317/75 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01)]

12 Claims

1. An isolated polypeptide comprising at least one VHH domain that binds 41BB, wherein each VHH domain that binds 41BB comprises a CDR1, a CDR2, and a CDR3, respectively, comprising the amino acid sequences of SEQ ID NOs: 26, 27 and 28; or SEQ ID NOs: 26, 61, and 28; or SEQ ID NOs: 26, 63, and 28; or SEQ ID NOs: 26, 71, and 28; or SEQ ID NOs: 26, 73, and 28; or SEQ ID NOs: 26, 75, and 28; or SEQ ID NOs: 26, 77, and 28; or SEQ ID NOs: 26, 79, and 28; or SEQ ID NOs: 65, 61, and 28; or SEQ ID NOs: 67, 61, and 28; or SEQ ID NOs: 69, 61, and 28.