	US 12,187,799 B2
	Dual specificity antibodies to PD-L1 and PD-L2 and methods of use therefor
Michael A. Curran, Houston, TX (US); Ashvin R. Jaiswal, Houston, TX (US); Dongxing Zha, Houston, TX (US); Kui Voo, Houston, TX (US); Carlo Toniatti, Houston, TX (US); Bianka Prinz, Lebanon, NH (US); Nga Rewa Houston, Lebanon, NH (US); and Eric Krauland, Lebanon, NH (US)
Assigned to Board of Regents, The University of Texas System, Austin, TX (US)
Appl. No. 17/040,329
Filed by Board of Regents, The University of Texas System, Austin, TX (US)
PCT Filed Mar. 15, 2019, PCT No. PCT/US2019/022491 § 371(c)(1), (2) Date Sep. 22, 2020, PCT Pub. No. WO2019/182896, PCT Pub. Date Sep. 26, 2019.
Claims priority of provisional application 62/647,562, filed on Mar. 23, 2018.
Prior Publication US 2021/0214445 A1, Jul. 15, 2021
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C12N 5/12 (2006.01); G01N 33/574 (2006.01)

CPC C07K 16/2827 (2013.01) [A61P 35/00 (2018.01); C07K 16/2896 (2013.01); C12N 5/12 (2013.01); G01N 33/57492 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/54 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/80 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01)]

17 Claims

1. A bispecific antibody or antibody fragment that binds to PD-L1 and PD-L2 comprising a first and a second set of heavy and light chain CDR sequences comprising:

(i) heavy chain CDR1-3 sequences of SEQ ID NOS: 19-21 and light chain CDR-1-3 sequences of SEQ ID NOS: 22-24, or heavy chain CDR1-3 sequences of SEQ ID NOS: 25-27 and light chain CDR1-3 sequences of SEQ ID NOS: 28-30, and

(ii) heavy chain CDR1-3 sequences of SEQ ID NOS: 31-33 and light chain CDR1-3 sequences of SEQ ID NOS: 34-36, or heavy chain CDR1-3 sequences of SEQ ID NOS: 37-39 and light chain CDR1-3 sequences of SEQ ID NOS: 40-42.