	US 12,187,720 B2
	Compounds for treatment of cancer
Wei Li, Germantown, TN (US); Duane D Miller, Collierville, TN (US); Kinsie E. Arnst, Gulf Breeze, FL (US); and Dong-Jin Hwang, Arlington, TN (US)
Assigned to UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, Knoxville, TN (US)
Filed by ONCTERNAL THERAPEUTICS, INC., San Diego, CA (US); and UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, Knoxville, TN (US)
Filed on Jul. 8, 2021, as Appl. No. 17/370,201.
Application 17/370,201 is a continuation of application No. 16/281,291, filed on Feb. 21, 2019, granted, now 11,084,811.
Application 16/281,291 is a continuation in part of application No. 15/270,359, filed on Sep. 20, 2016, granted, now 11,465,987.
Application 15/270,359 is a continuation of application No. 13/676,650, filed on Nov. 14, 2012, granted, now 9,447,049, issued on Sep. 20, 2016.
Application 13/676,650 is a continuation in part of application No. 13/216,927, filed on Aug. 24, 2011, granted, now 8,822,513, issued on Sep. 2, 2014.
Application 13/216,927 is a continuation in part of application No. 12/981,233, filed on Dec. 29, 2010, granted, now 9,334,242.
Claims priority of provisional application 61/376,675, filed on Aug. 24, 2010.
Claims priority of provisional application 61/315,790, filed on Mar. 19, 2010.
Claims priority of provisional application 61/309,360, filed on Mar. 1, 2010.
Prior Publication US 2022/0024912 A1, Jan. 27, 2022
Int. Cl. C07D 417/14 (2006.01); A61P 35/00 (2006.01); C07C 49/786 (2006.01); C07D 211/14 (2006.01); C07D 213/76 (2006.01); C07D 217/04 (2006.01); C07D 233/64 (2006.01); C07D 277/24 (2006.01); C07D 405/06 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01)

CPC C07D 417/14 (2013.01) [A61P 35/00 (2018.01); C07C 49/786 (2013.01); C07D 211/14 (2013.01); C07D 213/76 (2013.01); C07D 217/04 (2013.01); C07D 233/64 (2013.01); C07D 277/24 (2013.01); C07D 405/06 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01)]

16 Claims

16. A compound, wherein the compound is at least one of 1-chloro-7-(4-fluorophenyl)isoquinoline, 7-(4-fluorophenyl)-1-(1H-indol-5-yl)isoquinoline, 7-(4-fluorophenyl)-1-(3,4,5-trimethoxyphenyl)isoquinoline, 1,7-bis(4-fluorophenyl)isoquinoline, 1,7-bis(3,4,5-trimethoxyphenyl)isoquinoline, 1-(4-fluorophenyl)-7-(3,4,5-trimethoxyphenyl)isoquinoline, 1-(1H-indol-5-yl)-7-(3,4,5-trimethoxyphenyl)isoquinoline, or 1-chloro-7-(3,4,5-trimethoxyphenyl)isoquinoline.