R¹ is H or halo;

G¹ is —N— or —C(R^b)—, wherein R^b is H or halo;

R² is H or —CH₃;

L¹, Y¹, and Y² are defined by (i) or (ii):

(i) L¹ is absent;

or

(ii) L¹

 wherein L² is absent, —O—, —NH—, or —OCH₂—*, and wherein * indicates the attachment to Y²;

R^x is

R^1a, R^1b, R^1c1, R^1c2, R^1f, R^1g, R^1h1, and R^1h2 are each independently H, alkyl, alkenyl, alkynyl, haloalkyl, —C(O)O-alkyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl;

R^1d1, R^1d2, and R^1d3 are each independently alkyl, alkenyl, alkynyl, —C(O)O— alkyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl;

R^1e1 and R^1e2 are each independently H, alkyl, alkenyl, alkynyl, haloalkyl, —C(O)O-alkyl, or a cycloalkyl, cycloalkenyl, cycloalkynyl, heterocycloalkyl, heterocycloalkenyl, or heteroaryl ring;

R^z is

R^2a, R^2b1, R^2b2, R^2c, R^2d1, R^2g2, R^2h, R²ⁱ, and R^2j are each independently selected from the group consisting of H, halo, —OH, —CN, —NR^cR^d, alkyl, alkenyl, alkynyl, —O-alkyl, haloalkyl, cycloalkyl, and —C(O)NR^cR^d;

R^2e, R^2f, R^2g1, and R^2g2 are each independently selected from the group consisting of halo, —OH, —CN, —NR^cR^d, alkyl, alkenyl, alkynyl, —O-alkyl, haloalkyl, cycloalkyl, and —C(O)NR^cR^d; and

R^c and R^d are each independently H or alkyl;

wherein, when Y¹ is

 at least one of (a)-(c) applies:

(a) R² is —CH₃;

(b) R¹ is halo; and

(c) G¹ is —C(R^b)—, wherein R^b is halo; and

when Y¹ is

 and Y² is

 R^2b1 is selected from the group consisting of H, halo, —OH, —CN, —NR^cR^d, alkyl, alkenyl, alkynyl, —O—C₂-C₆alkyl, haloalkyl, cycloalkyl, and —C(O)NR^cR^d.