US 12,187,696 B2
Urea motif containing compounds and derivatives thereof as antibacterial drugs
Philipp Le, Munich (DE); Stephan Sieber, Utting am Ammersee (DE); and Elena Kunold, Sundbyberg (SE)
Assigned to TECHNISCHE UNIVERSITÄT MÜNCHEN, Munich (DE)
Appl. No. 16/304,521
Filed by Technische Universität München, Munich (DE)
PCT Filed May 30, 2017, PCT No. PCT/EP2017/063014
§ 371(c)(1), (2) Date Nov. 26, 2018,
PCT Pub. No. WO2017/207556, PCT Pub. Date Dec. 7, 2017.
Claims priority of application No. 16171906 (EP), filed on May 30, 2016.
Prior Publication US 2021/0009550 A1, Jan. 14, 2021
Int. Cl. C07D 317/66 (2006.01); A61P 31/04 (2006.01); C07C 275/34 (2006.01); C07C 275/38 (2006.01); C07C 275/42 (2006.01); C07D 317/46 (2006.01)
CPC C07D 317/66 (2013.01) [A61P 31/04 (2018.01); C07C 275/34 (2013.01); C07C 275/38 (2013.01); C07C 275/42 (2013.01); C07D 317/46 (2013.01)] 10 Claims
 
1. A compound having a structure according to Formula II

OG Complex Work Unit Chemistry
wherein
R1 is cyano or halogen;
R2 is (C1-C6)alkyl or (C1-C6) haloalkyl;

OG Complex Work Unit Chemistry
R13 is selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6) haloalkyl and halogen; and
X is O or S;
or a pharmaceutically acceptable salt, solvate or hydrate thereof.