| CPC C07D 217/24 (2013.01) [C07C 39/14 (2013.01); C07C 39/15 (2013.01); C07C 43/202 (2013.01); C07C 43/23 (2013.01); C07C 49/83 (2013.01); C07C 63/38 (2013.01); C07C 211/58 (2013.01); C07C 215/86 (2013.01); C07C 233/65 (2013.01); C07C 235/66 (2013.01); C07C 311/08 (2013.01); C07C 311/24 (2013.01); C07C 311/29 (2013.01); C07C 317/22 (2013.01); C07D 209/34 (2013.01); C07D 211/22 (2013.01); C07D 213/30 (2013.01); C07D 217/02 (2013.01); C07D 231/20 (2013.01); C07D 235/26 (2013.01); C07D 241/42 (2013.01); C07D 295/084 (2013.01); G01N 33/502 (2013.01)] | 18 Claims |
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1. A compound or a pharmaceutically acceptable salt, a solvate, or a stereoisomer thereof,
wherein
the compound is a compound of formula (IIh);
 wherein
R1 is —O—, or —S—;
R3 is selected from the group consisting of: —O—, —S—, —N(Ra)—, and —C(Rb)2—; wherein Ra is selected from the group consisting of H, and C1-C4 alkyl, and Rb is each independently selected from the group consisting of H and C1-C6 alkyl;
L1 is substituted or unsubstituted C3-C8 cycloalkyl or unsubstituted C1-C6 alkylene group;
R7 is selected from the group consisting of: H, —OH, halogen, Rf—, Rf—O—, Rf—S—, Rf—C(O)O—, Rf—S(O)2—, Rf—S(O)—, Rf—C(O)—, NHRf, NH(SO2)Rf, and —R1a-L1a-Rda, wherein Rf is selected from the group consisting of: H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C6 cycloalkyl; R1a is —O—, or —S—; L1a is unsubstituted C1-C6 alkylene group, or substituted or unsubstituted C3-C8 cycloalkyl;
each R2 is independently selected from the group consisting of: H, and substituted or unsubstituted C1-C6 alkyl; or two R2 and the nitrogen atom to which they are attached form a substituted or unsubstituted 4 to 10 membered heterocyclic group, and the heterocyclyl contains 1 or 2 N atoms and 0, 1, or 2 O or S heteroatoms;
Rc, Rd and Rda are each independently selected from the group consisting of —OH, nitro, cyano, sulfonyl, R″, —N(R″)2—, R″—O—, R″—S—, R″—S(O)2—, R″—S(O)—, R″—C(O), R″—C(O)O—, and R″—OC(O)—;
n1 and n2 are each independently 0, 1, or 2;
each of m is independently 0, 1, 2 or 3; and
unless otherwise specified, the term “substituted” refers to one or more hydrogens in the group is replaced with an R′ group;
each R′ is independently selected from the group consisting of D, halogen, —OH, nitro, cyano, sulfonyl, R″, —N(R″), R″—O—, R″—S—, R″—S(O)2—, R″—S(O)—, R″—C(O), R″—C(O)O—, R″—OC(O)—, and oxo (O═); or when two R′ attached to the same carbon atom, the two R′ and the carbon atom to which they are attached form substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted 4 to 7 membered heterocyclic group or 5 to 7-membered heteroaryl;
R″ is each independently selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C10 aryl, 4- to 7-membered heterocycloalkyl, 5- to 7-membered heteroaryl, -C1-C4 alkylene-C3-C6 cycloalkyl, -C1-C4 alkylene-C6-C10 aryl, -C1-C4 alkylene-(4 to 7-membered heterocycloalkyl), and -C1-C4 alkylene-(5 to 7-membered heteroaryl); and in R″, the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocycloalkyl or heteroaryl, as a whole group or a partial group, is optionally substituted by a substituent selected from the group consisting of: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, —OH, nitro, cyano, sulfonyl, and amino;
or the compound is selected from the following table:
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